loratadine (CHEBI:6538)

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ChEBI Name	loratadine

ChEBI ID	CHEBI:6538

Definition	A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H₁-receptor antagonist commonly employed in the treatment of allergic disorders.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:94763

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Formula

C22H23ClN2O2

Net Charge

Average Mass

382.890

Monoisotopic Mass

382.14481

InChI

InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChIKey

JCCNYMKQOSZNPW-UHFFFAOYSA-N

SMILES

CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2

Roles Classification
Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anti-allergic agent A drug used to treat allergic reactions. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	loratadine (CHEBI:6538) has functional parent desloratadine (CHEBI:291342) loratadine (CHEBI:6538) has role anti-allergic agent (CHEBI:50857) loratadine (CHEBI:6538) has role cholinergic antagonist (CHEBI:48873) loratadine (CHEBI:6538) has role geroprotector (CHEBI:176497) loratadine (CHEBI:6538) has role H₁-receptor antagonist (CHEBI:37955) loratadine (CHEBI:6538) is a N-acylpiperidine (CHEBI:48591) loratadine (CHEBI:6538) is a benzocycloheptapyridine (CHEBI:48593) loratadine (CHEBI:6538) is a ethyl ester (CHEBI:23990) loratadine (CHEBI:6538) is a organochlorine compound (CHEBI:36683) loratadine (CHEBI:6538) is a tertiary carboxamide (CHEBI:140326)

IUPAC Name

ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Synonym	Source
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester	ChEBI

Last Modified

29 October 2021