Lorazepam (CHEBI:6539)

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ChEBI Name	Lorazepam

ChEBI ID	CHEBI:6539

Stars	This entity has been manually annotated by a third party.

Secondary ChEBI IDs	CHEBI:94326

Supplier Information

Download	Molfile XML SDF

Formulae

C15H10Cl2N2O2
C15H10Cl2N2O2

Net Charge

Average Mass

321.159

Monoisotopic Mass

320.01193

InChI

InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

InChIKey

DIWRORZWFLOCLC-UHFFFAOYSA-N

SMILES

C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl

Roles Classification
Biological Role(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

Application(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. (via benzodiazepine )

ChEBI Ontology
Outgoing	Lorazepam (CHEBI:6539) is a benzodiazepine (CHEBI:22720)

Registry Number	Type	Source
846-49-1	CAS Registry Number	DrugCentral

Last Modified

06 March 2017