mycophenolate sodium (CHEBI:67155)

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ChEBI Name	mycophenolate sodium

ChEBI ID	CHEBI:67155

Definition	An organic sodium salt that is the sodium salt of mycophenolic acid. An immunosuppressant, it is widely used to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C17H19NaO6

Net Charge

Average Mass

342.31890

Monoisotopic Mass

342.10793

InChI

InChI=1S/C17H20O6.Na/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3;/h4,20H,5-8H2,1-3H3,(H,18,19);/q;+1/p-1/b9-4+;

InChIKey

DOZYTHNHLLSNIK-JOKMOOFLSA-M

SMILES

[Na+].COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC([O-])=O

Roles Classification
Biological Role(s):	EC 1.1.1.205 (IMP dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.

Application(s):	immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.

ChEBI Ontology
Outgoing	mycophenolate sodium (CHEBI:67155) has part mycophenolate (CHEBI:62932) mycophenolate sodium (CHEBI:67155) has role EC 1.1.1.205 (IMP dehydrogenase) inhibitor (CHEBI:53746) mycophenolate sodium (CHEBI:67155) has role immunosuppressive agent (CHEBI:35705) mycophenolate sodium (CHEBI:67155) is a organic sodium salt (CHEBI:38700)

IUPAC Name

sodium (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate

Synonyms	Sources
mycophenolic acid monosodium salt	ChemIDplus
mycophenolic acid sodium salt	ChemIDplus
sodium mycophenolate	ChemIDplus

Brand Name	Source
Myfortic	ChemIDplus

Last Modified

01 October 2012