CHEBI:6723 - megestrol acetate

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ChEBI Name megestrol acetate ChEBI ID CHEBI:6723 Definition A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C24H32O4 Net Charge 0 Average Mass 370.48190 Monoisotopic Mass 370.21441 InChI InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 InChIKey RQZAXGRLVPAYTJ-GQFGMJRRSA-N SMILES [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C Roles Classification Biological Role(s): progestin A synthetic progestogen. Application(s): antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. appetite enhancer A drug which increases appetite. contraceptive drug A chemical substance that prevents or reduces the probability of conception. synthetic oral contraceptive An oral contraceptive which owes its effectiveness to synthetic preparation. View more via ChEBI Ontology ChEBI Ontology Outgoing megestrol acetate (CHEBI:6723) has functional parent megestrol (CHEBI:6722) megestrol acetate (CHEBI:6723) has role antineoplastic agent (CHEBI:35610) megestrol acetate (CHEBI:6723) has role appetite enhancer (CHEBI:50779) megestrol acetate (CHEBI:6723) has role contraceptive drug (CHEBI:49323) megestrol acetate (CHEBI:6723) has role progestin (CHEBI:59826) megestrol acetate (CHEBI:6723) has role synthetic oral contraceptive (CHEBI:49326) megestrol acetate (CHEBI:6723) is a 20-oxo steroid (CHEBI:36885) megestrol acetate (CHEBI:6723) is a 3-oxo-Δ4 steroid (CHEBI:47909) megestrol acetate (CHEBI:6723) is a acetate ester (CHEBI:47622) megestrol acetate (CHEBI:6723) is a steroid ester (CHEBI:47880) IUPAC Name 6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate Synonyms Sources 17-acetoxy-6-methylpregna-4,6-diene-3,20-dione ChemIDplus 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate ChemIDplus 17α-acetoxy-6-dehydro-6-methylprogesterone ChemIDplus 17α-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate ChemIDplus 6-dehydro-6-methyl-17α-acetoxyprogesterone ChemIDplus 6-methyl-17α-acetoxypregna-4,6-diene-3,20-dione ChemIDplus 6-methyl-17α-hydroxy-delta(sup 6)-progesterone acetate ChemIDplus 6-methyl-6-dehydro-17α-acetoxyprogesterone ChemIDplus 6-methyl-delta(sup 4,6)-pregnadien-17α-ol-3,20-dione acetate ChemIDplus 6-methyl-delta(sup 6)-dehydro-17α-acetoxyprogesterone ChemIDplus BDH 1298 ChemIDplus BDH-1298 ChEBI BDH1298 ChEBI SC 10363 ChemIDplus SC-10363 ChEBI SC10363 ChemIDplus Brand Names Sources Magestin DrugBank magestin ChemIDplus Maygace DrugBank Megace DrugBank Megeron ChemIDplus Megestat DrugBank Megestil DrugBank Megestin DrugBank Niagestin DrugBank Niagestin ChemIDplus Ovaban ChemIDplus Ovarid ChemIDplus Pallace ChemIDplus Volidan ChEBI Manual Xrefs Databases C08151 KEGG COMPOUND D00952 KEGG DRUG DB00351 DrugBank GB870286 Patent LMST02030118 LIPID MAPS Megestrol_acetate Wikipedia US2891079 Patent US3356573 Patent US3400137 Patent View more database links Registry Numbers Types Sources 1917291 Beilstein Registry Number Beilstein 595-33-5 CAS Registry Number NIST Chemistry WebBook 595-33-5 CAS Registry Number ChemIDplus Citations Types Sources 11986264 PubMed citation Europe PMC 27038209 PubMed citation Europe PMC 27218795 PubMed citation Europe PMC 27639080 PubMed citation Europe PMC 28986550 PubMed citation Europe PMC 29050522 PubMed citation Europe PMC 29095656 PubMed citation Europe PMC 29400904 PubMed citation Europe PMC 29442239 PubMed citation Europe PMC 29542279 PubMed citation Europe PMC 29581752 PubMed citation Europe PMC 30112227 PubMed citation Europe PMC 30157059 PubMed citation Europe PMC 31036192 PubMed citation Europe PMC 31359357 PubMed citation Europe PMC 31451262 PubMed citation Europe PMC 31462353 PubMed citation Europe PMC 31497435 PubMed citation Europe PMC 31961463 PubMed citation Europe PMC 32084501 PubMed citation Europe PMC 32122805 PubMed citation Europe PMC 32652300 PubMed citation Europe PMC 5320316 PubMed citation Europe PMC PMC7207385 PubMed Central citation Europe PMC Last Modified 02 October 2020