| Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. BPA is produced on an industrial scale by the condensation reaction of phenol and acetone. Global production in 2022 was estimated to be in the region of 10 million tonnes.
BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 65–70% of all BPA production. The manufacturing of epoxy resins and vinyl ester resins account for 25–30% of BPA use. The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. It is not a plasticizer, although it is often wrongly labelled as such.
The health effects of BPA have been the subject of prolonged public and scientific debate. BPA is a xenoestrogen, exhibiting hormone-like properties that mimic the effects of estrogen in the body. Although the effect is very weak, the pervasiveness of BPA-containing materials raises concerns, as exposure is effectively lifelong. Many BPA-containing materials are non-obvious but commonly encountered, and include coatings for the inside of food cans, clothing designs, shop receipts, and dental fillings. BPA has been investigated by public health agencies in many countries, as well as by the World Health Organization.
While normal exposure is below the level currently associated with risk, several jurisdictions have taken steps to reduce exposure on a precautionary basis, in particular by banning BPA from baby bottles. There is some evidence that BPA exposure in infants has decreased as a result of this. BPA-free plastics have also been introduced, which are manufactured using alternative bisphenols such as bisphenol S and bisphenol F, but there is also controversy around whether these are actually safer.
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InChI=1S/C16H18FN3O2/c1- 2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) |
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| CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N |
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Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
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potassium channel modulator
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anticonvulsant
A drug used to prevent seizures or reduce their severity.
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View more via ChEBI Ontology
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D-23129
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ChemIDplus
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D-23129
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KEGG COMPOUND
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Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate
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ChemIDplus
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ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate
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ChEBI
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N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester
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KEGG COMPOUND
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N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
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ChemIDplus
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150812-12-7
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CAS Registry Number
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KEGG COMPOUND
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150812-12-7
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CAS Registry Number
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ChemIDplus
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8072099
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Reaxys Registry Number
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Reaxys
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22991134
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PubMed citation
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Europe PMC
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