CHEBI:691037 - desoximetasone

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ChEBI Name desoximetasone
ChEBI ID CHEBI:691037
Definition Dexamethasone in which the hydroxy group at the 17α position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H29FO4
Net Charge 0
Average Mass 376.46170
Monoisotopic Mass 376.20499
InChI InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChIKey VWVSBHGCDBMOOT-IIEHVVJPSA-N
SMILES [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Roles Classification
Biological Role(s): hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
Application(s): anti-inflammatory drug
A substance that reduces or suppresses inflammation.
antipruritic drug
A drug, usually applied topically, that relieves pruritus (itching).
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ChEBI Ontology
Outgoing desoximetasone (CHEBI:691037) has role anti-inflammatory drug (CHEBI:35472)
desoximetasone (CHEBI:691037) has role antipruritic drug (CHEBI:59683)
desoximetasone (CHEBI:691037) is a 11β-hydroxy steroid (CHEBI:35346)
desoximetasone (CHEBI:691037) is a 20-oxo steroid (CHEBI:36885)
desoximetasone (CHEBI:691037) is a 21-hydroxy steroid (CHEBI:35344)
desoximetasone (CHEBI:691037) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166)
desoximetasone (CHEBI:691037) is a fluorinated steroid (CHEBI:50830)
desoximetasone (CHEBI:691037) is a glucocorticoid (CHEBI:24261)
desoximetasone (CHEBI:691037) is a primary α-hydroxy ketone (CHEBI:139590)
IUPAC Name
9-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
INNs Sources
desoximetasona ChemIDplus
desoximetasone ChemIDplus
desoximetasonum ChemIDplus
Synonyms Sources
(11β,16α)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione ChEBI
9α-fluoro-16α-methyl-Δ1-corticosterone ChEBI
desoxymethasone ChEBI
Manual Xrefs Databases
819 DrugCentral
BE314196 Patent
D03697 KEGG DRUG
DB00547 DrugBank
Desoximetasone Wikipedia
FR1296544 Patent
US3099654 Patent
US3232839 Patent
View more database links
Registry Numbers Types Sources
2228097 Beilstein Registry Number Beilstein
382-67-2 CAS Registry Number ChemIDplus
Last Modified
06 February 2018