CHEBI:6997 - moricizine

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ChEBI Name moricizine
ChEBI ID CHEBI:6997
Definition A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:239866
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Formula C22H25N3O4S
Net Charge 0
Average Mass 427.51700
Monoisotopic Mass 427.15658
InChI InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)
InChIKey FUBVWMNBEHXPSU-UHFFFAOYSA-N
SMILES CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN3CCOCC3)c2c1
Roles Classification
Application(s): anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
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ChEBI Ontology
Outgoing moricizine (CHEBI:6997) has role anti-arrhythmia drug (CHEBI:38070)
moricizine (CHEBI:6997) is a carbamate ester (CHEBI:23003)
moricizine (CHEBI:6997) is a morpholines (CHEBI:38785)
moricizine (CHEBI:6997) is a phenothiazines (CHEBI:38093)
Incoming moricizine hydrochloride (CHEBI:60937) has part moricizine (CHEBI:6997)
IUPAC Name
ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate
INNs Sources
moracizina ChemIDplus
moracizine KEGG DRUG
moracizinum ChemIDplus
Synonyms Sources
[10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester ChEMBL
EN-313 ChEMBL
ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate ChemIDplus
ethyl 10-(β-N-morpholinylpropionyl)phenothiazine-2-carbamate ChEBI
Moricizine KEGG COMPOUND
Manual Xrefs Databases
1842 DrugCentral
C07743 KEGG COMPOUND
D05077 KEGG DRUG
DB00680 DrugBank
DE2014201 Patent
LSM-2476 LINCS
Moricizine Wikipedia
US3740395 Patent
View more database links
Registry Numbers Types Sources
31883-05-3 CAS Registry Number ChemIDplus
592021 Reaxys Registry Number Reaxys
Last Modified
22 February 2017
General Comment
2011-01-11 A class I anti-arrhythmic, moricizine acts on the heart muscle to improve the heart's rhythm. It has potent local anaesthetic activity and membrane stabilizing effect, and is used as the hydrochloride in the treatment of serious symptomatic ventricular arrhythmias.