CHEBI:7477 - naproxen sodium

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ChEBI Name naproxen sodium
ChEBI ID CHEBI:7477
Definition An organic sodium salt consisting of equimolar amounts of naproxen(1−) anions and sodium anions.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formulae C14H13NaO3
C14H13O3.Na
Net Charge 0
Average Mass 252.24100
Monoisotopic Mass 252.07624
InChI InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
InChIKey CDBRNDSHEYLDJV-FVGYRXGTSA-M
SMILES [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
cyclooxygenase 2 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
cyclooxygenase 1 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
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ChEBI Ontology
Outgoing naproxen sodium (CHEBI:7477) has part naproxen(1−) (CHEBI:59527)
naproxen sodium (CHEBI:7477) has role antipyretic (CHEBI:35493)
naproxen sodium (CHEBI:7477) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
naproxen sodium (CHEBI:7477) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
naproxen sodium (CHEBI:7477) has role non-narcotic analgesic (CHEBI:35481)
naproxen sodium (CHEBI:7477) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
naproxen sodium (CHEBI:7477) is a organic sodium salt (CHEBI:38700)
IUPAC Name
sodium (2S)-2-(6-methoxy-2-naphthyl)propanoate
Synonym Source
(−)-Sodium (S)-6-methoxy-α-methyl-2-naphthaleneacetate ChemIDplus
Manual Xrefs Databases
D00970 KEGG DRUG
DB00788 DrugBank
View more database links
Registry Numbers Types Sources
26159-34-2 CAS Registry Number ChemIDplus
6378035 Beilstein Registry Number Beilstein
Last Modified
21 August 2017