CHEBI:7953 - pemoline

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ChEBI Name pemoline ChEBI ID CHEBI:7953 Definition A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C9H8N2O2 Net Charge 0 Average Mass 176.17200 Monoisotopic Mass 176.05858 InChI InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12) InChIKey NRNCYVBFPDDJNE-UHFFFAOYSA-N SMILES NC1=NC(=O)C(O1)c1ccccc1 Roles Classification Application(s): central nervous system stimulant Any drug that enhances the activity of the central nervous system. View more via ChEBI Ontology ChEBI Ontology Outgoing pemoline (CHEBI:7953) has role central nervous system stimulant (CHEBI:35337) pemoline (CHEBI:7953) is a 1,3-oxazoles (CHEBI:46812) IUPAC Name 2-amino-5-phenyl-1,3-oxazol-4(5H)-one INNs Sources pemolina WHO MedNet pémoline WHO MedNet pemoline WHO MedNet pemolinum WHO MedNet Synonyms Sources 2-Amino-5-phenyl-4(5H)-oxazolone ChemIDplus 2-imino-4-keto-5-phenyltetrahydrooxazole ChemIDplus 2-imino-5-phenyl-4-oxazolidinone ChemIDplus 5-phenyl-2-imino-4-oxazolidinone ChemIDplus 5-phenyl-2-imino-4-oxooxazolidine ChemIDplus 5-phenylisohydantion ChemIDplus pheniminooxazolidinone DrugBank phenylisohydantoin DrugBank phenylpseudohydantoin DrugBank Brand Names Sources Azoxodon DrugBank Betanamin DrugBank Cylert KEGG DRUG Dantromin DrugBank Deltamine DrugBank Hyton DrugBank Myamin DrugBank Nitan DrugBank Notair DrugBank Manual Xrefs Databases 2075 DrugCentral C07899 KEGG COMPOUND D00744 KEGG DRUG DB01230 DrugBank LSM-5159 LINCS Pemoline Wikipedia View more database links Registry Numbers Types Sources 151559 Reaxys Registry Number Reaxys 2152-34-3 CAS Registry Number ChemIDplus 2152-34-3 CAS Registry Number NIST Chemistry WebBook Citations Types Sources 11216184 PubMed citation Europe PMC 2210262 PubMed citation Europe PMC 2303976 PubMed citation Europe PMC 2388127 PubMed citation Europe PMC 4021028 PubMed citation Europe PMC 641739 PubMed citation Europe PMC 772696 PubMed citation Europe PMC Last Modified 22 February 2017