| Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use (especially with codeine). Promethazine is taken by mouth (oral), as a rectal suppository, or by injection into a muscle (IM).
Common side effects of promethazine include confusion and sleepiness; consumption of alcohol or other sedatives can make these symptoms worse. It is unclear if use of promethazine during pregnancy or breastfeeding is safe for the fetus. Use of promethazine is not recommended in those less than two years old, due to potentially negative effects on breathing. Use of promethazine by injection into a vein is not recommended, due to potential skin damage. Promethazine is in the phenothiazine family of medications. It is also a strong anticholinergic, which produces its sedative effects. This also means high or toxic doses can act as a deliriant.
Promethazine was made in the 1940s by a team of scientists from Rhône-Poulenc laboratories. It was approved for medical use in the United States in 1951. It is a generic medication and is available under many brand names globally. In 2022, it was the 198th most commonly prescribed medication in the United States, with more than 2 million prescriptions. In 2022, the combination with dextromethorphan was the 260th most commonly prescribed medication in the United States, with more than 1 million prescriptions. |
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| InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3 |
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Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
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anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
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sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
local anaesthetic
Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
antipruritic drug
A drug, usually applied topically, that relieves pruritus (itching).
anti-allergic agent
A drug used to treat allergic reactions.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
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View more via ChEBI Ontology
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N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
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prometazina
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ChEBI
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prométhazine
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ChEBI
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promethazine
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ChEBI
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promethazinum
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ChEBI
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(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
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ChemIDplus
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10-(2-Dimethylaminopropyl)phenothiazine
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KEGG COMPOUND
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10-[2-(dimethylamino)propyl]phenothiazine
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NIST Chemistry WebBook
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N,N,α-trimethyl-10H-phenothiazine-10-ethanamine
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NIST Chemistry WebBook
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N-(2'-dimethylamino-2'-methyl)ethylphenothiazine
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ChemIDplus
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proazamine
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ChemIDplus
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Promethazine
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KEGG COMPOUND
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337077
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Gmelin Registry Number
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Gmelin
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60-87-7
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CAS Registry Number
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KEGG COMPOUND
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60-87-7
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CAS Registry Number
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NIST Chemistry WebBook
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60-87-7
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CAS Registry Number
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ChemIDplus
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88554
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Reaxys Registry Number
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Reaxys
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2011-02-04
