CHEBI:8717 - quinethazone

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ChEBI Name quinethazone
ChEBI ID CHEBI:8717
Definition A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB3409585, eMolecules:732041, Selleckchem:Tangeretin(Tangeritin), ZINC000001531699
Download Molfile XML SDF
Formula C10H12ClN3O3S
Net Charge 0
Average Mass 289.740
Monoisotopic Mass 289.02879
InChI InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
InChIKey AGMMTXLNIQSRCG-UHFFFAOYSA-N
SMILES C12=C(C=C(S(N)(=O)=O)C(=C1)Cl)C(NC(N2)CC)=O
Roles Classification
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
diuretic
An agent that promotes the excretion of urine through its effects on kidney function.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing quinethazone (CHEBI:8717) has role antihypertensive agent (CHEBI:35674)
quinethazone (CHEBI:8717) has role diuretic (CHEBI:35498)
quinethazone (CHEBI:8717) is a quinazolines (CHEBI:38530)
IUPAC Name
7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
Synonym Source
7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide ChEBI
Manual Xrefs Databases
C07342 KEGG COMPOUND
D00461 KEGG DRUG
LSM-1666 LINCS
US9393221 Patent
View more database links
Registry Numbers Types Sources
73-49-4 CAS Registry Number KEGG COMPOUND
818554 Reaxys Registry Number Reaxys
Citations Types Sources
13953345 PubMed citation Europe PMC
14066683 PubMed citation Europe PMC
14085918 PubMed citation Europe PMC
14160213 PubMed citation Europe PMC
28166217 PubMed citation Europe PMC
4896145 PubMed citation Europe PMC
Last Modified
19 June 2017