CHEBI:90365 - EC 4.6.1.1 (adenylate cyclase) inhibitor

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ChEBI Name EC 4.6.1.1 (adenylate cyclase) inhibitor
ChEBI ID CHEBI:90365
Definition An EC 4.6.* (P‒O lyase) inhibitor that interferes with the action of enzyme adenylate cyclase (EC 4.6.1.1).
Stars This entity has been manually annotated by the ChEBI Team.
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Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: ATP = 3′,5′-cyclic AMP + diphosphate It has key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters3',5'-cyclic AMP.
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ChEBI Ontology
Outgoing EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365) is a EC 4.6.* (PO lyase) inhibitor (CHEBI:76716)
Incoming 2',3'-dideoxyadenosine (CHEBI:91207) has role EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365)
9-(tetrahydrofuryl)adenine (CHEBI:90232) has role EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365)
Synonyms Sources
3',5'-cyclic AMP synthetase inhibitor ChEBI
3',5'-cyclic AMP synthetase inhibitors ChEBI
adenyl cyclase inhibitor ChEBI
adenylate cyclase (EC 4.6.1.1) inhibitor ChEBI
adenylate cyclase (EC 4.6.1.1) inhibitors ChEBI
adenylate cyclase inhibitor ChEBI
adenylate cyclase inhibitors ChEBI
adenylyl cyclase inhibitor ChEBI
adenylyl cyclase inhibitors ChEBI
adenylylcyclase inhibitor ChEBI
adenylylcyclase inhibitors ChEBI
ATP diphosphate-lyase (cyclising) inhibitor ChEBI
ATP diphosphate-lyase (cyclising) inhibitors ChEBI
ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitor ChEBI
ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitors ChEBI
ATP diphosphate-lyase (cyclizing) inhibitor ChEBI
ATP diphosphate-lyase (cyclizing) inhibitors ChEBI
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitor ChEBI
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitors ChEBI
ATP pyrophosphate-lyase inhibitor ChEBI
ATP pyrophosphate-lyase inhibitors ChEBI
EC 4.6.1.1 (adenylate cyclase) inhibitors ChEBI
EC 4.6.1.1 inhibitor ChEBI
EC 4.6.1.1 inhibitors ChEBI
Manual Xref Database
Adenylyl_cyclase Wikipedia
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Citations
Last Modified
15 February 2016