CHEBI:90365 - EC 4.6.1.1 (adenylate cyclase) inhibitor

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ChEBI Name EC 4.6.1.1 (adenylate cyclase) inhibitor ChEBI ID CHEBI:90365 Definition An EC 4.6.* (P‒O lyase) inhibitor that interferes with the action of enzyme adenylate cyclase (EC 4.6.1.1). Stars This entity has been manually annotated by the ChEBI Team. Wikipedia License Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: ATP = 3′,5′-cyclic AMP + diphosphate It has key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters3',5'-cyclic AMP. Read full article at Wikipedia ChEBI Ontology Outgoing EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365) is a EC 4.6.* (P‒O lyase) inhibitor (CHEBI:76716) Incoming 2',3'-dideoxyadenosine (CHEBI:91207) has role EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365) 9-(tetrahydrofuryl)adenine (CHEBI:90232) has role EC 4.6.1.1 (adenylate cyclase) inhibitor (CHEBI:90365) Synonyms Sources 3',5'-cyclic AMP synthetase inhibitor ChEBI 3',5'-cyclic AMP synthetase inhibitors ChEBI adenyl cyclase inhibitor ChEBI adenylate cyclase (EC 4.6.1.1) inhibitor ChEBI adenylate cyclase (EC 4.6.1.1) inhibitors ChEBI adenylate cyclase inhibitor ChEBI adenylate cyclase inhibitors ChEBI adenylyl cyclase inhibitor ChEBI adenylyl cyclase inhibitors ChEBI adenylylcyclase inhibitor ChEBI adenylylcyclase inhibitors ChEBI ATP diphosphate-lyase (cyclising) inhibitor ChEBI ATP diphosphate-lyase (cyclising) inhibitors ChEBI ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitor ChEBI ATP diphosphate-lyase (cyclising; 3',5'-cyclic-AMP-forming) inhibitors ChEBI ATP diphosphate-lyase (cyclizing) inhibitor ChEBI ATP diphosphate-lyase (cyclizing) inhibitors ChEBI ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitor ChEBI ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitors ChEBI ATP pyrophosphate-lyase inhibitor ChEBI ATP pyrophosphate-lyase inhibitors ChEBI EC 4.6.1.1 (adenylate cyclase) inhibitors ChEBI EC 4.6.1.1 inhibitor ChEBI EC 4.6.1.1 inhibitors ChEBI Manual Xref Database Adenylyl_cyclase Wikipedia View more database links Citations Last Modified 15 February 2016