CHEBI:91367 - AZD-1152

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ChEBI Name AZD-1152
ChEBI ID CHEBI:91367
Definition A member of the of quinazolines that is 4-aminoquinazolin-7-ol in which the amino group at position 4 has been substituted by a 5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl group, while the hydroxy group at position 7 has been converted into the corresponding 3-[ethyl(2-hydroxyethyl)aminopropyl ether.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C26H30FN7O3
Net Charge 0
Average Mass 507.570
Monoisotopic Mass 507.23942
InChI InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChIKey QYZOGCMHVIGURT-UHFFFAOYSA-N
SMILES CCN(CCO)CCCOC1=CC2=C(C=C1)C(NC1=NNC(CC(=O)NC3=CC(F)=CC=C3)=C1)=NC=N2
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): Aurora kinase inhibitor
Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing AZD-1152 (CHEBI:91367) has role antineoplastic agent (CHEBI:35610)
AZD-1152 (CHEBI:91367) has role Aurora kinase inhibitor (CHEBI:70770)
AZD-1152 (CHEBI:91367) is a anilide (CHEBI:13248)
AZD-1152 (CHEBI:91367) is a monofluorobenzenes (CHEBI:83575)
AZD-1152 (CHEBI:91367) is a primary alcohol (CHEBI:15734)
AZD-1152 (CHEBI:91367) is a pyrazoles (CHEBI:26410)
AZD-1152 (CHEBI:91367) is a quinazolines (CHEBI:38530)
AZD-1152 (CHEBI:91367) is a secondary amino compound (CHEBI:50995)
AZD-1152 (CHEBI:91367) is a secondary carboxamide (CHEBI:140325)
AZD-1152 (CHEBI:91367) is a tertiary amino compound (CHEBI:50996)
Incoming AZT-1152 (CHEBI:167636) has functional parent AZD-1152 (CHEBI:91367)
IUPAC Name
2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
Synonyms Sources
AZD-2811 ChemIDplus
AZD1152 ChEBI
Manual Xref Database
LSM-1067 LINCS
View more database links
Registry Number Type Source
722544-51-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
18367484 PubMed citation Europe PMC
20159992 PubMed citation Europe PMC
25277659 PubMed citation Europe PMC
25752998 PubMed citation Europe PMC
28639950 PubMed citation Europe PMC
29197031 PubMed citation Europe PMC
30051358 PubMed citation Europe PMC
Last Modified
17 March 2021