sulfasalazine (CHEBI:9334)

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ChEBI Name	sulfasalazine

ChEBI ID	CHEBI:9334

Definition	An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:101223

Supplier Information

Download	Molfile XML SDF

Formula

C18H14N4O5S

Net Charge

Average Mass

398.39300

Monoisotopic Mass

398.06849

InChI

InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

InChIKey

NCEXYHBECQHGNR-QZQOTICOSA-N

SMILES

OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1

Roles Classification
Biological Role(s):	drug allergen Any drug which causes the onset of an allergic reaction. ferroptosis inducer Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. EC 2.5.1.18 (glutathione transferase) inhibitor An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of a glutathione transferase (EC 2.5.1.18).

Application(s):	drug allergen Any drug which causes the onset of an allergic reaction. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.

ChEBI Ontology
Outgoing	sulfasalazine (CHEBI:9334) has functional parent sulfanilamide (CHEBI:45373) sulfasalazine (CHEBI:9334) has role antiinfective agent (CHEBI:35441) sulfasalazine (CHEBI:9334) has role drug allergen (CHEBI:88188) sulfasalazine (CHEBI:9334) has role EC 2.5.1.18 (glutathione transferase) inhibitor (CHEBI:76797) sulfasalazine (CHEBI:9334) has role ferroptosis inducer (CHEBI:173085) sulfasalazine (CHEBI:9334) has role gastrointestinal drug (CHEBI:55324) sulfasalazine (CHEBI:9334) has role non-steroidal anti-inflammatory drug (CHEBI:35475) sulfasalazine (CHEBI:9334) is a azobenzenes (CHEBI:22682) sulfasalazine (CHEBI:9334) is a pyridines (CHEBI:26421) sulfasalazine (CHEBI:9334) is a sulfonamide (CHEBI:35358)

IUPAC Name

2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid

Synonyms	Sources
2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid	ChemIDplus
2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid	ChEMBL
4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene	ChemIDplus
5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid	ChemIDplus
5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid	ChemIDplus
5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid	ChemIDplus
Salazosulfapyridine	KEGG COMPOUND
Salicylazosulfapyridine	KEGG COMPOUND
Sulfasalazine	KEGG COMPOUND

Brand Name	Source
Azulfidine	KEGG DRUG

Last Modified

26 May 2021