AmiGO 2: Term Details for "nuclear exosome (RNase complex)" (GO:0000176)

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Term Information

Accession: GO:0000176
Name: nuclear exosome (RNase complex)
Ontology: cellular_component
Synonyms: eukaryotic exosome multienzyme ribonuclease complex, nuclear exosome (ribonuclease complex), nuclear exosome multienzyme ribonuclease complex
Alternate IDs: None
Definition: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. Source: PMID:26726035, PMID:17174896, PMID:20531386
Comment: None
History: See term history for GO:0000176 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to nuclear exosome (RNase complex) (excluding "regulates").; Link to all direct and indirect annotations to nuclear exosome (RNase complex) (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nuclear exosome (RNase complex) (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
GO:0008150 biological_process
GO:0003824 catalytic activity
CARO:0000000 anatomical entity
GO:0009987 cellular process
GO:0016787 hydrolase activity
GO:0008152 metabolic process
UBERON:0001062 anatomical entity
GO:0009058 biosynthetic process
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0044237 cellular metabolic process
GO:0016788 hydrolase activity, acting on ester bonds
CARO:0000006 material anatomical entity
GO:0003674 molecular_function
GO:0071704 organic substance metabolic process
GO:0005488 binding
GO:0009056 catabolic process
GO:0140098 catalytic activity, acting on RNA
GO:0110165 cellular anatomical entity
GO:0044249 cellular biosynthetic process
CARO:0000003 connected anatomical structure
GO:0004527 exonuclease activity
GO:0043170 macromolecule metabolic process
UBERON:0000465 material anatomical entity
GO:0004518 nuclease activity
GO:0006139 nucleobase-containing compound metabolic process
GO:0043226 organelle
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:1901575 organic substance catabolic process
GO:0044238 primary metabolic process
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0005622 intracellular anatomical structure
GO:0043229 intracellular organelle
GO:0009059 macromolecule biosynthetic process
GO:0043227 membrane-bounded organelle
GO:0031974 membrane-enclosed lumen
GO:0090304 nucleic acid metabolic process
GO:0097159 organic cyclic compound binding
GO:1901361 organic cyclic compound catabolic process
GO:0032991 protein-containing complex
GO:0004532 RNA exonuclease activity
GO:0004540 RNA nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:1902494 catalytic complex
CL:0000000 cell
GO:0010467 gene expression
GO:0043231 intracellular membrane-bounded organelle
GO:0009057 macromolecule catabolic process
GO:0003676 nucleic acid binding
GO:0141188 nucleic acid catabolic process
GO:0034655 nucleobase-containing compound catabolic process
GO:0043233 organelle lumen
PR:000050567 protein-containing material entity
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters
GO:0016070 RNA metabolic process
GO:0000175 3'-5'-RNA exonuclease activity
GO:1905354 exoribonuclease complex
GO:0070013 intracellular organelle lumen
GO:0005634 nucleus
GO:0003723 RNA binding
GO:0006401 RNA catabolic process
GO:0006396 RNA processing
GO:0000178 exosome (RNase complex)
GO:0031981 nuclear lumen
GO:0140513 nuclear protein-containing complex
GO:0000176 nuclear exosome (RNase complex)
GO:0101019 nucleolar exosome (RNase complex)

Parents of nuclear exosome (RNase complex) (GO:0000176)

subject	relation	object
nuclear exosome (RNase complex)	is_a	nuclear protein-containing complex (GO:0140513)
nuclear exosome (RNase complex)	is_a	exosome (RNase complex) (GO:0000178)
nuclear exosome (RNase complex)	BFO:0000050	nucleus (GO:0005634)
nuclear exosome (RNase complex)	BFO:0000050	nuclear lumen (GO:0031981)

Children of nuclear exosome (RNase complex) (GO:0000176)

subject	relation	object
nuclear exosome focus (GO:1990251)	BFO:0000051	nuclear exosome (RNase complex)
nucleolar exosome (RNase complex) (GO:0101019)	is_a	nuclear exosome (RNase complex)

nuclear exosome (RNase complex)