AmiGO 2: Term Details for "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" (GO:0000252)

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Term Information

Accession: GO:0000252
Name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
Ontology: molecular_function
Synonyms: 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating), 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity, C-3 sterol dehydrogenase (C-4 decarboxylase) activity, C-3 sterol dehydrogenase activity, sterol 4alpha-carboxylic decarboxylase activity, sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity, sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
Alternate IDs: None
Definition: Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. Source: PMID:9811880, EC:1.1.1.170
Comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
History: See term history for GO:0000252 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity (excluding "regulates").; Link to all direct and indirect annotations to C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity

Parents of C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity (GO:0000252)

subject	relation	object
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	is_a	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)

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EC: 1.1.1.170
Reactome: R-HSA-194642; R-HSA-194718