AmiGO 2: Term Details for "C-4 methylsterol oxidase activity" (GO:0000254)

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Term Information

Accession: GO:0000254
Name: C-4 methylsterol oxidase activity
Ontology: molecular_function
Synonyms: 4-methylsterol oxidase activity, methylsterol hydroxylase activity, methylsterol monooxygenase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O. Source: PMID:9811880, RHEA:55220
Comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
History: See term history for GO:0000254 at QuickGO
Chem. react.: has participant hydron; has participant iron(3+); has participant iron(2+); has participant 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate; has participant dioxygen; has participant water; has participant 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol
Subset: None
Related: Link to all genes and gene products annotated to C-4 methylsterol oxidase activity (excluding "regulates").; Link to all direct and indirect annotations to C-4 methylsterol oxidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for C-4 methylsterol oxidase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0004497 monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0000254 C-4 methylsterol oxidase activity

Parents of C-4 methylsterol oxidase activity (GO:0000254)

subject	relation	object
C-4 methylsterol oxidase activity	is_a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen (GO:0016716)
C-4 methylsterol oxidase activity	RO:0000057	hydron (CHEBI:15378)
C-4 methylsterol oxidase activity	RO:0000057	iron(3+) (CHEBI:29034)
C-4 methylsterol oxidase activity	RO:0000057	iron(2+) (CHEBI:29033)
C-4 methylsterol oxidase activity	RO:0000057	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate (CHEBI:58387)
C-4 methylsterol oxidase activity	RO:0000057	dioxygen (CHEBI:15379)
C-4 methylsterol oxidase activity	RO:0000057	water (CHEBI:15377)
C-4 methylsterol oxidase activity	RO:0000057	4,4-dimethyl-5alpha-cholest-7-en-3beta-ol (CHEBI:16455)

This term has no children.

EC: 1.14.18.9
MetaCyc: RXN-13188
Reactome: R-HSA-194641; R-HSA-194669
RHEA: 55220