AmiGO 2: Term Details for "nitrilase activity" (GO:0000257)

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Term Information

Accession: GO:0000257
Name: nitrilase activity
Ontology: molecular_function
Synonyms: acetonitrilase activity, benzonitrilase activity, nitrile aminohydrolase activity
Alternate IDs: None
Definition: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. Source: EC:3.5.5.1, GOC:kd
Comment: None
History: See term history for GO:0000257 at QuickGO
Chem. react.: has participant nitrile; has participant carboxylic acid anion; has participant water; has participant ammonium
Subset: None
Related: Link to all genes and gene products annotated to nitrilase activity (excluding "regulates").; Link to all direct and indirect annotations to nitrilase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nitrilase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016815 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
GO:0000257 nitrilase activity
GO:0018762 aliphatic nitrilase activity
GO:0047428 arylacetonitrilase activity
GO:0018761 bromoxynil nitrilase activity
GO:0047427 cyanoalanine nitrilase activity
GO:0080061 indole-3-acetonitrile nitrilase activity
GO:0047426 ricinine nitrilase activity

Parents of nitrilase activity (GO:0000257)

subject	relation	object
nitrilase activity	RO:0000057	nitrile (CHEBI:18379)
nitrilase activity	RO:0000057	carboxylic acid anion (CHEBI:29067)
nitrilase activity	RO:0000057	water (CHEBI:15377)
nitrilase activity	RO:0000057	ammonium (CHEBI:28938)
nitrilase activity	is_a	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles (GO:0016815)

Children of nitrilase activity (GO:0000257)

subject	relation	object
ricinine nitrilase activity (GO:0047426)	is_a	nitrilase activity
aliphatic nitrilase activity (GO:0018762)	is_a	nitrilase activity
cyanoalanine nitrilase activity (GO:0047427)	is_a	nitrilase activity
indole-3-acetonitrile nitrilase activity (GO:0080061)	is_a	nitrilase activity
arylacetonitrilase activity (GO:0047428)	is_a	nitrilase activity
bromoxynil nitrilase activity (GO:0018761)	is_a	nitrilase activity

EC: 3.5.5.1
KEGG_REACTION: R00540
MetaCyc: 3.5.5.1-RXN
RHEA: 21724
UM-BBD_enzymeID: e0283