obsolete second U2-type spliceosomal transesterification activity
Ontology
molecular_function
Synonyms
second U2-type spliceosomal transesterification activity, 3'-splice site cleavage, exon ligation
Alternate IDs
None
Definition
OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.
Source:
GOC:krc,
ISBN:0879695897
Comment
This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
Link
to all genes and gene products annotated to obsolete second U2-type spliceosomal transesterification activity (excluding "regulates").
Link
to all direct and indirect annotations
to obsolete second U2-type spliceosomal transesterification activity (excluding "regulates").
Link
to all direct and indirect annotations download (limited to first 10,000)
for obsolete second U2-type spliceosomal transesterification activity (excluding "regulates").