AmiGO 2: Term Details for "second spliceosomal transesterification activity" (GO:0000386)

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Term Information

Accession: GO:0000386
Name: second spliceosomal transesterification activity
Ontology: molecular_function
Synonyms: lariat formation, 5'-splice site cleavage, 3'-splice site cleavage, exon ligation
Alternate IDs: None
Definition: Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. Source: GOC:krc, PMID:19239890, ISBN:0879695897
Comment: None
History: See term history for GO:0000386 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to second spliceosomal transesterification activity (excluding "regulates").; Link to all direct and indirect annotations to second spliceosomal transesterification activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for second spliceosomal transesterification activity (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0044237 cellular metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0009058 biosynthetic process
GO:0006725 cellular aromatic compound metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0046483 heterocycle metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
GO:0044249 cellular biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0009059 macromolecule biosynthetic process
GO:0090304 nucleic acid metabolic process
GO:0010467 gene expression
GO:0003674 molecular_function
GO:0016070 RNA metabolic process
GO:0003824 catalytic activity
GO:0006396 RNA processing
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0008380 RNA splicing
GO:0140098 catalytic activity, acting on RNA
GO:0000375 RNA splicing, via transesterification reactions
GO:0000386 second spliceosomal transesterification activity
GO:0071013 catalytic step 2 spliceosome

Parents of second spliceosomal transesterification activity (GO:0000386)

subject	relation	object
second spliceosomal transesterification activity	is_a	catalytic activity, acting on RNA (GO:0140098)
second spliceosomal transesterification activity	BFO:0000050	RNA splicing, via transesterification reactions (GO:0000375)

Children of second spliceosomal transesterification activity (GO:0000386)

subject	relation	object
catalytic step 2 spliceosome (GO:0071013)	RO:0002215	second spliceosomal transesterification activity

Reactome: R-HSA-9770236