AmiGO 2: Term Details for "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity" (GO:0000703)

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Term Information

Accession: GO:0000703
Name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Ontology: molecular_function
Synonyms: oxidized pyrimidine base lesion DNA N-glycosylase activity, endodeoxyribonuclease III, endonuclease III, endonuclease VIII activity, pyrimidine-specific oxidized base lesion DNA N-glycosylase activity, DNA glycosylase/AP-lyase, DNA glycosylase/beta-lyase, bifunctional DNA glycosylase
Alternate IDs: GO:0019004
Definition: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Source: PMID:11554296, GOC:elh
Comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
History: See term history for GO:0000703 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations to oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016787 hydrolase activity
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0140097 catalytic activity, acting on DNA
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0034042 5-formyluracil DNA N-glycosylase activity
GO:0034043 5-hydroxymethyluracil DNA N-glycosylase activity

Parents of oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (GO:0000703)

subject	relation	object
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	is_a	oxidized base lesion DNA N-glycosylase activity (GO:0000702)

Children of oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (GO:0000703)

subject	relation	object
5-formyluracil DNA N-glycosylase activity (GO:0034042)	is_a	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
5-hydroxymethyluracil DNA N-glycosylase activity (GO:0034043)	is_a	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Reactome: R-HSA-110227; R-HSA-110226; R-HSA-110224