AmiGO 2: Term Details for "pyrimidine dimer DNA N-glycosylase activity" (GO:0000704)

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Term Information

Accession: GO:0000704
Name: pyrimidine dimer DNA N-glycosylase activity
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Source: PMID:9224623, GOC:elh
Comment: None
History: See term history for GO:0000704 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to pyrimidine dimer DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations to pyrimidine dimer DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for pyrimidine dimer DNA N-glycosylase activity (excluding "regulates").