AmiGO 2: Term Details for "peptide amidation" (GO:0001519)

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Term Information

Accession: GO:0001519
Name: peptide amidation
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions. Source: PMID:11028916
Comment: None
History: See term history for GO:0001519 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to peptide amidation (excluding "regulates").; Link to all direct and indirect annotations to peptide amidation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for peptide amidation (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0006518 peptide metabolic process
GO:0031179 peptide modification
GO:0001519 peptide amidation

Parents of peptide amidation (GO:0001519)

subject	relation	object
peptide amidation	is_a	peptide modification (GO:0031179)

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