AmiGO 2: Term Details for "release of cytochrome c from mitochondria" (GO:0001836)

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Term Information

Accession: GO:0001836
Name: release of cytochrome c from mitochondria
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. Source: PMID:9560217, GOC:add, GOC:mah, PMID:12925707, GOC:mtg_apoptosis, ISBN:0721639976
Comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
History: See term history for GO:0001836 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to release of cytochrome c from mitochondria (excluding "regulates").; Link to all direct and indirect annotations to release of cytochrome c from mitochondria (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for release of cytochrome c from mitochondria (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0065007 biological regulation
GO:0071840 cellular component organization or biogenesis
GO:0008219 cell death
GO:0016043 cellular component organization
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0006996 organelle organization
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0008637 apoptotic mitochondrial changes
GO:0097190 apoptotic signaling pathway
GO:0001836 release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090199 regulation of release of cytochrome c from mitochondria

Parents of release of cytochrome c from mitochondria (GO:0001836)

subject	relation	object
release of cytochrome c from mitochondria	BFO:0000050	apoptotic signaling pathway (GO:0097190)
release of cytochrome c from mitochondria	is_a	apoptotic mitochondrial changes (GO:0008637)

Children of release of cytochrome c from mitochondria (GO:0001836)

subject	relation	object
positive regulation of release of cytochrome c from mitochondria (GO:0090200)	RO:0002213	release of cytochrome c from mitochondria
regulation of release of cytochrome c from mitochondria (GO:0090199)	RO:0002211	release of cytochrome c from mitochondria
negative regulation of release of cytochrome c from mitochondria (GO:0090201)	RO:0002212	release of cytochrome c from mitochondria

release of cytochrome c from mitochondria