Term Information

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Accession
GO:0001913
Name
T cell mediated cytotoxicity
Ontology
biological_process
Synonyms
T cell mediated apoptosis, T cell mediated cell death, T cell mediated cell killing, T lymphocyte mediated cytotoxicity, T-cell mediated apoptosis, T-cell mediated cell death, T-cell mediated cell killing, T-cell mediated cytotoxicity, T-lymphocyte mediated cytotoxicity, T cell mediated cytolysis
Alternate IDs
None
Definition
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: GOC:pr, ISBN:0781735149, GOC:add, PMID:11911826
Comment
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
History
See term history for GO:0001913 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of T cell mediated cytotoxicity (GO:0001913)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
T cell mediated cytotoxicity [is_a relation] is_a  T cell mediated immunity (GO:0002456)
T cell mediated cytotoxicity [RO:0002608 relation] RO:0002608  T cell (CL:0000084)
T cell mediated cytotoxicity [is_a relation] is_a  leukocyte mediated cytotoxicity (GO:0001909)
Children of T cell mediated cytotoxicity (GO:0001913)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of T cell mediated cytotoxicity (GO:0001914) [RO:0002211 relation] RO:0002211  T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity (GO:0001916) [RO:0002213 relation] RO:0002213  T cell mediated cytotoxicity
T cell mediated cytotoxicity directed against tumor cell target (GO:0002419) [is_a relation] is_a  T cell mediated cytotoxicity
negative regulation of T cell mediated cytotoxicity (GO:0001915) [RO:0002212 relation] RO:0002212  T cell mediated cytotoxicity
cytotoxic T cell degranulation (GO:0043316) [BFO:0000050 relation] BFO:0000050  T cell mediated cytotoxicity
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