AmiGO 2: Term Details for "podosome" (GO:0002102)

Accession: GO:0002102
Name: podosome
Ontology: cellular_component
Synonyms: None
Alternate IDs: None
Definition: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. Source: PMID:15890982, PMID:12837608
Comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
History: See term history for GO:0002102 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to podosome (excluding "regulates").; Link to all direct and indirect annotations to podosome (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for podosome (excluding "regulates").