AmiGO 2: Term Details for "germinal center B cell differentiation" (GO:0002314)

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Term Information

Accession: GO:0002314
Name: germinal center B cell differentiation
Ontology: biological_process
Synonyms: germinal center B lymphocyte differentiation, germinal center B-cell differentiation, germinal center B-lymphocyte differentiation, germinal center B cell development
Alternate IDs: None
Definition: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). Source: ISBN:0781735149, GOC:jal
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History: See term history for GO:0002314 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to germinal center B cell differentiation (excluding "regulates").; Link to all direct and indirect annotations to germinal center B cell differentiation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for germinal center B cell differentiation (excluding "regulates").

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GO:0008150 biological_process
GO:0032502 developmental process
GO:0048856 anatomical structure development
GO:0030154 cell differentiation
GO:0048869 cellular developmental process
GO:0009987 cellular process
GO:0048468 cell development
GO:0030097 hemopoiesis
GO:0002376 immune system process
GO:0032501 multicellular organismal process
GO:0050896 response to stimulus
GO:0001775 cell activation
GO:0002252 immune effector process
GO:0006955 immune response
GO:0002521 leukocyte differentiation
GO:0002263 cell activation involved in immune response
GO:0045321 leukocyte activation
GO:0046649 lymphocyte activation
GO:1903131 mononuclear cell differentiation
GO:0042113 B cell activation
GO:0002366 leukocyte activation involved in immune response
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002335 mature B cell differentiation
GO:0002313 mature B cell differentiation involved in immune response
GO:0002314 germinal center B cell differentiation

Parents of germinal center B cell differentiation (GO:0002314)

subject	relation	object
germinal center B cell differentiation	is_a	mature B cell differentiation involved in immune response (GO:0002313)
germinal center B cell differentiation	RO:0002315	germinal center B cell (CL:0000844)

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