AmiGO 2: Term Details for "marginal zone B cell differentiation" (GO:0002315)

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Term Information

Accession: GO:0002315
Name: marginal zone B cell differentiation
Ontology: biological_process
Synonyms: marginal zone B lymphocyte differentiation, marginal zone B-cell differentiation, marginal zone B-lymphocyte differentiation, marginal zone B cell development
Alternate IDs: None
Definition: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). Source: ISBN:0781735149, GOC:jal
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History: See term history for GO:0002315 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to marginal zone B cell differentiation (excluding "regulates").; Link to all direct and indirect annotations to marginal zone B cell differentiation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for marginal zone B cell differentiation (excluding "regulates").

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GO:0008150 biological_process
GO:0032502 developmental process
GO:0048856 anatomical structure development
GO:0030154 cell differentiation
GO:0048869 cellular developmental process
GO:0009987 cellular process
GO:0048468 cell development
GO:0030097 hemopoiesis
GO:0002376 immune system process
GO:0032501 multicellular organismal process
GO:0050896 response to stimulus
GO:0001775 cell activation
GO:0002252 immune effector process
GO:0006955 immune response
GO:0002521 leukocyte differentiation
GO:0002263 cell activation involved in immune response
GO:0045321 leukocyte activation
GO:0046649 lymphocyte activation
GO:1903131 mononuclear cell differentiation
GO:0042113 B cell activation
GO:0002366 leukocyte activation involved in immune response
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002335 mature B cell differentiation
GO:0002313 mature B cell differentiation involved in immune response
GO:0002315 marginal zone B cell differentiation

Parents of marginal zone B cell differentiation (GO:0002315)

subject	relation	object
marginal zone B cell differentiation	is_a	mature B cell differentiation involved in immune response (GO:0002313)
marginal zone B cell differentiation	RO:0002315	marginal zone B cell of spleen (CL:0000845)

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