AmiGO 2: Term Details for "B cell affinity maturation" (GO:0002344)

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Term Information

Accession: GO:0002344
Name: B cell affinity maturation
Ontology: biological_process
Synonyms: B lymphocyte affinity maturation, B-cell affinity maturation, B-lymphocyte affinity maturation
Alternate IDs: None
Definition: The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. Source: ISBN:0781735149, GO_REF:0000022, GOC:jal
Comment: None
History: See term history for GO:0002344 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to B cell affinity maturation (excluding "regulates").; Link to all direct and indirect annotations to B cell affinity maturation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for B cell affinity maturation (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0032502 developmental process
GO:0048856 anatomical structure development
GO:0030154 cell differentiation
GO:0048869 cellular developmental process
GO:0009987 cellular process
GO:0048468 cell development
GO:0008152 metabolic process
GO:0032501 multicellular organismal process
GO:0009058 biosynthetic process
GO:0001775 cell activation
GO:0044237 cellular metabolic process
GO:0030097 hemopoiesis
GO:0002376 immune system process
GO:0071704 organic substance metabolic process
GO:0050896 response to stimulus
GO:0044249 cellular biosynthetic process
GO:0002252 immune effector process
GO:0006955 immune response
GO:0045321 leukocyte activation
GO:0002521 leukocyte differentiation
GO:0043170 macromolecule metabolic process
GO:1901576 organic substance biosynthetic process
GO:0002250 adaptive immune response
GO:0002443 leukocyte mediated immunity
GO:0046649 lymphocyte activation
GO:0009059 macromolecule biosynthetic process
GO:1903131 mononuclear cell differentiation
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0042113 B cell activation
GO:0010467 gene expression
GO:0030098 lymphocyte differentiation
GO:0002449 lymphocyte mediated immunity
GO:0030183 B cell differentiation
GO:0019724 B cell mediated immunity
GO:0002440 production of molecular mediator of immune response
GO:0002339 B cell selection
GO:0016064 immunoglobulin mediated immune response
GO:0002377 immunoglobulin production
GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response
GO:0002343 peripheral B cell selection
GO:0002344 B cell affinity maturation
GO:0002205 somatic hypermutation of immunoglobulin genes involved in immune response

Parents of B cell affinity maturation (GO:0002344)

subject	relation	object
B cell affinity maturation	is_a	peripheral B cell selection (GO:0002343)
B cell affinity maturation	BFO:0000050	immunoglobulin production involved in immunoglobulin-mediated immune response (GO:0002381)

Children of B cell affinity maturation (GO:0002344)

subject	relation	object
memory B cell (CL:0000787)	RO:0002353	B cell affinity maturation
naive B cell (CL:0000788)	CL:4030044	B cell affinity maturation
somatic hypermutation of immunoglobulin genes involved in immune response (GO:0002205)	BFO:0000050	B cell affinity maturation

B cell affinity maturation