AmiGO 2: Term Details for "T cell mediated cytotoxicity directed against tumor cell target" (GO:0002419)

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Term Information

Accession: GO:0002419
Name: T cell mediated cytotoxicity directed against tumor cell target
Ontology: biological_process
Synonyms: T lymphocyte mediated cytotoxicity directed against tumor cell target, T-cell mediated cytotoxicity directed against tumor cell target, T-lymphocyte mediated cytotoxicity directed against tumor cell target
Alternate IDs: None
Definition: The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: PMID:16730260, ISBN:0781735149, GOC:add
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
History: See term history for GO:0002419 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to T cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").; Link to all direct and indirect annotations to T cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for T cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").

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GO:0008150 biological_process
GO:0006955 immune response
GO:0002376 immune system process
GO:0050896 response to stimulus
GO:0002250 adaptive immune response
GO:0009987 cellular process
GO:0002252 immune effector process
GO:0002443 leukocyte mediated immunity
GO:0009607 response to biotic stimulus
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0001906 cell killing
GO:0002449 lymphocyte mediated immunity
GO:0002347 response to tumor cell
GO:0002418 immune response to tumor cell
GO:0001909 leukocyte mediated cytotoxicity
GO:0002456 T cell mediated immunity
GO:0001913 T cell mediated cytotoxicity
GO:0002424 T cell mediated immune response to tumor cell
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002853 negative regulation of T cell mediated cytotoxicity directed against tumor cell target
GO:0002854 positive regulation of T cell mediated cytotoxicity directed against tumor cell target
GO:0002852 regulation of T cell mediated cytotoxicity directed against tumor cell target

Parents of T cell mediated cytotoxicity directed against tumor cell target (GO:0002419)

subject	relation	object
T cell mediated cytotoxicity directed against tumor cell target	is_a	T cell mediated immune response to tumor cell (GO:0002424)
T cell mediated cytotoxicity directed against tumor cell target	is_a	T cell mediated cytotoxicity (GO:0001913)

Children of T cell mediated cytotoxicity directed against tumor cell target (GO:0002419)

subject	relation	object
positive regulation of T cell mediated cytotoxicity directed against tumor cell target (GO:0002854)	RO:0002213	T cell mediated cytotoxicity directed against tumor cell target
regulation of T cell mediated cytotoxicity directed against tumor cell target (GO:0002852)	RO:0002211	T cell mediated cytotoxicity directed against tumor cell target
negative regulation of T cell mediated cytotoxicity directed against tumor cell target (GO:0002853)	RO:0002212	T cell mediated cytotoxicity directed against tumor cell target

T cell mediated cytotoxicity directed against tumor cell target