AmiGO 2: Term Details for "natural killer cell mediated cytotoxicity directed against tumor cell target" (GO:0002420)

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Term Information

Accession: GO:0002420
Name: natural killer cell mediated cytotoxicity directed against tumor cell target
Ontology: biological_process
Synonyms: NK cell mediated cytotoxicity directed against tumor cell target
Alternate IDs: None
Definition: The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: PMID:16730260, ISBN:0781735149, GOC:add
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
History: See term history for GO:0002420 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to natural killer cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").; Link to all direct and indirect annotations to natural killer cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for natural killer cell mediated cytotoxicity directed against tumor cell target (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0050896 response to stimulus
GO:0008150 biological_process
GO:0009607 response to biotic stimulus
GO:0009605 response to external stimulus
GO:0044419 biological process involved in interspecies interaction between organisms
GO:0043207 response to external biotic stimulus
GO:0006950 response to stress
GO:0006952 defense response
GO:0051707 response to other organism
GO:0098542 defense response to other organism
GO:0002376 immune system process
GO:0009987 cellular process
GO:0140546 defense response to symbiont
GO:0002252 immune effector process
GO:0006955 immune response
GO:0002443 leukocyte mediated immunity
GO:0001906 cell killing
GO:0045087 innate immune response
GO:0002449 lymphocyte mediated immunity
GO:0002347 response to tumor cell
GO:0002418 immune response to tumor cell
GO:0001909 leukocyte mediated cytotoxicity
GO:0002228 natural killer cell mediated immunity
GO:0042267 natural killer cell mediated cytotoxicity
GO:0002423 natural killer cell mediated immune response to tumor cell
GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Parents of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420)

subject	relation	object
natural killer cell mediated cytotoxicity directed against tumor cell target	is_a	natural killer cell mediated immune response to tumor cell (GO:0002423)
natural killer cell mediated cytotoxicity directed against tumor cell target	is_a	natural killer cell mediated cytotoxicity (GO:0042267)

Children of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420)

subject	relation	object
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002858)	RO:0002211	natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860)	RO:0002213	natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002859)	RO:0002212	natural killer cell mediated cytotoxicity directed against tumor cell target

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