Term Information

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Accession
GO:0002951
Name
leukotriene-C(4) hydrolase
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate. Source: RHEA:31563, PMID:9774450
Comment
The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione.
History
See term history for GO:0002951 at QuickGO
Chem. react.
has participant water
has participant leukotriene C4(2-)
has participant L-glutamate(1-)
has participant leukotriene D4(1-)
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0002951 from QuickGO

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Parents of leukotriene-C(4) hydrolase (GO:0002951)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
leukotriene-C(4) hydrolase [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
leukotriene-C(4) hydrolase [is_a relation] is_a  omega peptidase activity (GO:0008242)
leukotriene-C(4) hydrolase [RO:0000057 relation] RO:0000057  leukotriene C4(2-) (CHEBI:57973)
leukotriene-C(4) hydrolase [RO:0000057 relation] RO:0000057  L-glutamate(1-) (CHEBI:29985)
leukotriene-C(4) hydrolase [RO:0000057 relation] RO:0000057  leukotriene D4(1-) (CHEBI:63166)

This term has no children.

EC
3.4.19.14
RHEA
31563