AmiGO 2: Term Details for "transcription coregulator activity" (GO:0003712)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0003712
Name: transcription coregulator activity
Ontology: molecular_function
Synonyms: transcription cofactor activity, transcriptional co-regulator, RNA polymerase II transcriptional cofactor activity
Alternate IDs: GO:0001104, GO:0016455
Definition: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867, Wikipedia:Transcription_coregulator, PMID:24203923, PMID:25957681
Comment: Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.
History: See term history for GO:0003712 at QuickGO
Chem. react.: None
Subset: goslim_drosophila
Related: Link to all genes and gene products annotated to transcription coregulator activity (excluding "regulates").; Link to all direct and indirect annotations to transcription coregulator activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for transcription coregulator activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0003674 molecular_function
GO:0060090 molecular adaptor activity
GO:0030674 protein-macromolecule adaptor activity
GO:0140110 transcription regulator activity
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity

Parents of transcription coregulator activity (GO:0003712)

subject	relation	object
transcription coregulator activity	is_a	transcription regulator activity (GO:0140110)
transcription coregulator activity	is_a	protein-macromolecule adaptor activity (GO:0030674)

Children of transcription coregulator activity (GO:0003712)

subject	relation	object
transcription coactivator activity (GO:0003713)	is_a	transcription coregulator activity
transcription corepressor activity (GO:0003714)	is_a	transcription coregulator activity

transcription coregulator activity