Term Information

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Accession
GO:0003714
Name
transcription corepressor activity
Ontology
molecular_function
Synonyms
transcription co-repressor activity, RNA polymerase II transcription co-repressor activity, RNA polymerase II transcription corepressor activity
Alternate IDs
GO:0001106
Definition
A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: GOC:txnOH-2018, PMID:10213677, PMID:16858867
Comment
For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
History
See term history for GO:0003714 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0003714 from QuickGO

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Parents of transcription corepressor activity (GO:0003714)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription corepressor activity [BFO:0000050 relation] BFO:0000050  negative regulation of DNA-templated transcription (GO:0045892)
transcription corepressor activity [is_a relation] is_a  transcription coregulator activity (GO:0003712)
Children of transcription corepressor activity (GO:0003714)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear receptor corepressor activity (GO:0140536) [is_a relation] is_a  transcription corepressor activity
sigma factor antagonist activity (GO:0016989) [is_a relation] is_a  transcription corepressor activity
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