AmiGO 2: Term Details for "protein-glutamine gamma-glutamyltransferase activity" (GO:0003810)

Term Information

Accession: GO:0003810
Name: protein-glutamine gamma-glutamyltransferase activity
Ontology: molecular_function
Synonyms: TGase activity, fibrinoligase activity, transglutaminase activity, R-glutaminyl-peptide:amine gamma-glutamyl transferase activity, factor XIIIa, fibrin stabilizing factor, glutaminylpeptide gamma-glutamyltransferase activity, polyamine transglutaminase activity, protein-glutamine:amine gamma-glutamyltransferase, tissue transglutaminase
Alternate IDs: None
Definition: Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. Source: EC:2.3.2.13
Comment: None
History: See term history for GO:0003810 at QuickGO
Chem. react.: has participant ammonium; has participant L-glutamine residue; has participant N(6)-(gamma-glutamyl)lysine residue; has participant L-lysinium residue
Subset: None
Related: Link to all genes and gene products annotated to protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations to protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016755 aminoacyltransferase activity
GO:0140096 catalytic activity, acting on a protein
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0150074 positive regulation of protein-glutamine gamma-glutamyltransferase activity

Parents of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)

subject	relation	object
protein-glutamine gamma-glutamyltransferase activity	is_a	catalytic activity, acting on a protein (GO:0140096)
protein-glutamine gamma-glutamyltransferase activity	is_a	aminoacyltransferase activity (GO:0016755)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	ammonium (CHEBI:28938)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	L-glutamine residue (CHEBI:30011)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	N(6)-(gamma-glutamyl)lysine residue (CHEBI:138370)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	L-lysinium residue (CHEBI:29969)

Children of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)

subject	relation	object
cornified envelope assembly (GO:1903575)	BFO:0000051	protein-glutamine gamma-glutamyltransferase activity
positive regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150074)	RO:0002213	protein-glutamine gamma-glutamyltransferase activity

EC: 2.3.2.13
MetaCyc: 2.3.2.13-RXN
Reactome: R-HSA-140851; R-HSA-6810894
RESID: AA0124
RHEA: 54816