AmiGO 2: Term Details for "protein-glutamine gamma-glutamyltransferase activity" (GO:0003810)

Term Information

Accession: GO:0003810
Name: protein-glutamine gamma-glutamyltransferase activity
Ontology: molecular_function
Synonyms: TGase activity, fibrinoligase activity, transglutaminase activity, R-glutaminyl-peptide:amine gamma-glutamyl transferase activity, factor XIIIa, fibrin stabilizing factor, glutaminylpeptide gamma-glutamyltransferase activity, polyamine transglutaminase activity, protein-glutamine:amine gamma-glutamyltransferase, tissue transglutaminase
Alternate IDs: None
Definition: Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. Source: EC:2.3.2.13
Comment: None
History: See term history for GO:0003810 at QuickGO
Chem. react.: has participant ammonium; has participant L-glutamine residue; has participant N(6)-(gamma-glutamyl)lysine residue; has participant L-lysinium residue
Subset: None
Related: Link to all genes and gene products annotated to protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations to protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for protein-glutamine gamma-glutamyltransferase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016755 aminoacyltransferase activity
GO:0140096 catalytic activity, acting on a protein
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0150074 positive regulation of protein-glutamine gamma-glutamyltransferase activity

Parents of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)

subject	relation	object
protein-glutamine gamma-glutamyltransferase activity	is_a	catalytic activity, acting on a protein (GO:0140096)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	ammonium (CHEBI:28938)
protein-glutamine gamma-glutamyltransferase activity	is_a	aminoacyltransferase activity (GO:0016755)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	L-glutamine residue (CHEBI:30011)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	N(6)-(gamma-glutamyl)lysine residue (CHEBI:138370)
protein-glutamine gamma-glutamyltransferase activity	RO:0000057	L-lysinium residue (CHEBI:29969)

Children of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)

subject	relation	object
cornified envelope assembly (GO:1903575)	BFO:0000051	protein-glutamine gamma-glutamyltransferase activity
positive regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150074)	RO:0002213	protein-glutamine gamma-glutamyltransferase activity

EC: 2.3.2.13
MetaCyc: 2.3.2.13-RXN
Reactome: R-HSA-140851; R-HSA-6810894
RESID: AA0124
RHEA: 54816