AmiGO 2: Term Details for "2-isopropylmalate synthase activity" (GO:0003852)

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Term Information

Accession: GO:0003852
Name: 2-isopropylmalate synthase activity
Ontology: molecular_function
Synonyms: 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity, acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming), alpha-IPM synthetase activity, alpha-isopropylmalate synthase activity, alpha-isopropylmalate synthetase activity, alpha-isopropylmalic synthetase activity, isopropylmalate synthase activity, isopropylmalate synthetase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. Source: RHEA:21524
Comment: Note that this function was formerly EC:4.1.3.12.
History: See term history for GO:0003852 at QuickGO
Chem. react.: has participant 3-methyl-2-oxobutanoate; has participant (2S)-2-isopropylmalate(2-); has participant water; has participant acetyl-CoA(4-); has participant hydron; has participant coenzyme A(4-)
Subset: None
Related: Link to all genes and gene products annotated to 2-isopropylmalate synthase activity (excluding "regulates").; Link to all direct and indirect annotations to 2-isopropylmalate synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for 2-isopropylmalate synthase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0003852 2-isopropylmalate synthase activity

Parents of 2-isopropylmalate synthase activity (GO:0003852)

subject	relation	object
2-isopropylmalate synthase activity	RO:0000057	3-methyl-2-oxobutanoate (CHEBI:11851)
2-isopropylmalate synthase activity	RO:0000057	(2S)-2-isopropylmalate(2-) (CHEBI:1178)
2-isopropylmalate synthase activity	RO:0000057	water (CHEBI:15377)
2-isopropylmalate synthase activity	RO:0000057	acetyl-CoA(4-) (CHEBI:57288)
2-isopropylmalate synthase activity	is_a	acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912)
2-isopropylmalate synthase activity	RO:0000057	hydron (CHEBI:15378)
2-isopropylmalate synthase activity	RO:0000057	coenzyme A(4-) (CHEBI:57287)

This term has no children.

EC: 2.3.3.13
KEGG_REACTION: R01213
MetaCyc: 2-ISOPROPYLMALATESYN-RXN
RHEA: 21524