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DNA-(apurinic or apyrimidinic site) endonuclease activity

Term Information

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Accession
GO:0003906
Name
DNA-(apurinic or apyrimidinic site) endonuclease activity
Ontology
molecular_function
Synonyms
AP deoxyendoribonuclease activity, abasic deoxyendoribonuclease activity, apurinic deoxyendoribonuclease activity, apurinic/apyrimidinic endodeoxyribonuclease activity, apyrimidinic deoxyendoribonuclease activity, deoxyribonuclease (apurinic or apyrimidinic) activity, endonuclease VIII activity, UV endonuclease
Alternate IDs
None
Definition
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). Source: Wikipedia:AP_endonuclease
Comment
Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
History
See term history for GO:0003906 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0003906 from QuickGO

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Parents of DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA-(apurinic or apyrimidinic site) endonuclease activity [is_a relation] is_a  catalytic activity, acting on DNA (GO:0140097)
Children of DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140080) [is_a relation] is_a  DNA-(apurinic or apyrimidinic site) endonuclease activity
class II DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0052720) [is_a relation] is_a  DNA-(apurinic or apyrimidinic site) endonuclease activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078) [is_a relation] is_a  DNA-(apurinic or apyrimidinic site) endonuclease activity