AmiGO 2: Term Details for "DNA topoisomerase type I (single strand cut, ATP-independent) activity" (GO:0003917)

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Term Information

Accession: GO:0003917
Name: DNA topoisomerase type I (single strand cut, ATP-independent) activity
Ontology: molecular_function
Synonyms: type I DNA topoisomerase activity, type I topoisomerase activity, nicking-closing enzyme activity, omega-protein activity, relaxing enzyme activity, swivelase activity, untwisting enzyme activity, DNA topoisomerase I activity, deoxyribonucleate topoisomerase, topoisomerase
Alternate IDs: None
Definition: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. Source: PMID:8811192
Comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
History: See term history for GO:0003917 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to DNA topoisomerase type I (single strand cut, ATP-independent) activity (excluding "regulates").; Link to all direct and indirect annotations to DNA topoisomerase type I (single strand cut, ATP-independent) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for DNA topoisomerase type I (single strand cut, ATP-independent) activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0140097 catalytic activity, acting on DNA
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0140225 DNA topoisomerase III-beta-TDRD3 complex

Parents of DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)

subject	relation	object
DNA topoisomerase type I (single strand cut, ATP-independent) activity	is_a	DNA topoisomerase activity (GO:0003916)

Children of DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)

subject	relation	object
DNA topoisomerase III-beta-TDRD3 complex (GO:0140225)	RO:0002216	DNA topoisomerase type I (single strand cut, ATP-independent) activity

EC: 5.6.2.1
MetaCyc: 5.99.1.2-RXN