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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Term Information

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Accession
GO:0003918
Name
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Ontology
molecular_function
Synonyms
DNA topoisomerase type II activity, DNA topoisomerase (ATP-hydrolysing), type II DNA topoisomerase activity, DNA topoisomerase II, DNA topoisomerase II activity, DNA topoisomerase IV activity, topoisomerase II, deoxyribonucleate topoisomerase, deoxyribonucleic topoisomerase activity, topoisomerase
Alternate IDs
GO:0061505
Definition
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. Source: PMID:8811192
Comment
None
History
See term history for GO:0003918 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0003918 from QuickGO

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Parents of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [is_a relation] is_a  DNA topoisomerase activity (GO:0003916)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [is_a relation] is_a  ATP-dependent activity, acting on DNA (GO:0008094)
Children of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity (GO:0072587) [RO:0002629 relation] RO:0002629  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity (GO:2000372) [RO:0002212 relation] RO:0002212  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
regulation of DNA topoisomerase (ATP-hydrolyzing) activity (GO:2000371) [RO:0002211 relation] RO:0002211  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity (GO:0008657) [RO:0002630 relation] RO:0002630  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (GO:0009330) [RO:0002216 relation] RO:0002216  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
DNA negative supercoiling activity (GO:0034335) [is_a relation] is_a  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity (GO:2000373) [RO:0002213 relation] RO:0002213  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity (GO:0072586) [RO:0002578 relation] RO:0002578  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity