AmiGO 2: Term Details for "arachidonate 5-lipoxygenase activity" (GO:0004051)

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Term Information

Accession: GO:0004051
Name: arachidonate 5-lipoxygenase activity
Ontology: molecular_function
Synonyms: 5-delta-lipoxygenase activity, 5-lipoxygenase activity, 5Delta-lipoxygenase activity, C-5-lipoxygenase activity, arachidonate:oxygen 5-oxidoreductase activity, arachidonic 5-lipoxygenase activity, arachidonic acid 5-lipoxygenase activity, delta(5)-lipoxygenase activity, delta5-lipoxygenase activity, leukotriene-A4 synthase activity, LTA synthase activity, leukotriene-A(4) synthase activity, leukotriene A4 synthase
Alternate IDs: None
Definition: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. Source: EC:1.13.11.34, RHEA:32307
Comment: None
History: See term history for GO:0004051 at QuickGO
Chem. react.: has participant arachidonate; has participant leukotriene A4(1-); has participant dioxygen; has participant water
Subset: None
Related: Link to all genes and gene products annotated to arachidonate 5-lipoxygenase activity (excluding "regulates").; Link to all direct and indirect annotations to arachidonate 5-lipoxygenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for arachidonate 5-lipoxygenase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0051213 dioxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004051 arachidonate 5-lipoxygenase activity
GO:0002180 5-lipoxygenase complex

Parents of arachidonate 5-lipoxygenase activity (GO:0004051)

subject	relation	object
arachidonate 5-lipoxygenase activity	RO:0000057	arachidonate (CHEBI:32395)
arachidonate 5-lipoxygenase activity	is_a	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)
arachidonate 5-lipoxygenase activity	RO:0000057	leukotriene A4(1-) (CHEBI:57463)
arachidonate 5-lipoxygenase activity	RO:0000057	dioxygen (CHEBI:15379)
arachidonate 5-lipoxygenase activity	RO:0000057	water (CHEBI:15377)

Children of arachidonate 5-lipoxygenase activity (GO:0004051)

subject	relation	object
5-lipoxygenase complex (GO:0002180)	RO:0002215	arachidonate 5-lipoxygenase activity

EC: 1.13.11.34
MetaCyc: ARACHIDONATE-5-LIPOXYGENASE-RXN
Reactome: R-HSA-9025999; R-HSA-9026405; R-HSA-9020282; R-HSA-9018863; R-HSA-9020264; R-HSA-9025995; R-HSA-9026005; R-HSA-9027633; R-HSA-9025996; R-HSA-9018894; R-HSA-265296; R-HSA-9024997; R-HSA-9020256; R-HSA-9018859; R-HSA-9020278; R-HSA-9020259; R-HSA-9027628; R-HSA-266051; R-HSA-9020251; R-HSA-9020277; R-HSA-9018858; R-HSA-9020255; R-HSA-9027624
RHEA: 32307