AmiGO 2: Term Details for "arachidonate 12(S)-lipoxygenase activity" (GO:0004052)

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Term Information

Accession: GO:0004052
Name: arachidonate 12(S)-lipoxygenase activity
Ontology: molecular_function
Synonyms: 12-lipoxygenase activity, 12Delta-lipoxygenase activity, 12S-lipoxygenase activity, C-12 lipoxygenase activity, LTA4 synthase activity, arachidonate:oxygen 12-oxidoreductase activity, delta12-lipoxygenase activity, leukotriene A4 synthase
Alternate IDs: None
Definition: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. Source: RHEA:10428, EC:1.13.11.31
Comment: None
History: See term history for GO:0004052 at QuickGO
Chem. react.: has participant arachidonate; has participant dioxygen; has participant 12(S)-HPETE(1-)
Subset: None
Related: Link to all genes and gene products annotated to arachidonate 12(S)-lipoxygenase activity (excluding "regulates").; Link to all direct and indirect annotations to arachidonate 12(S)-lipoxygenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for arachidonate 12(S)-lipoxygenase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0051213 dioxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004052 arachidonate 12(S)-lipoxygenase activity

Parents of arachidonate 12(S)-lipoxygenase activity (GO:0004052)

subject	relation	object
arachidonate 12(S)-lipoxygenase activity	RO:0000057	arachidonate (CHEBI:32395)
arachidonate 12(S)-lipoxygenase activity	is_a	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)
arachidonate 12(S)-lipoxygenase activity	RO:0000057	dioxygen (CHEBI:15379)
arachidonate 12(S)-lipoxygenase activity	RO:0000057	12(S)-HPETE(1-) (CHEBI:57444)

This term has no children.

EC: 1.13.11.31
KEGG_REACTION: R01596
MetaCyc: ARACHIDONATE-12-LIPOXYGENASE-RXN
Reactome: R-HSA-9025957; R-HSA-2161948; R-HSA-9026006; R-HSA-9024983; R-HSA-2161950; R-HSA-2161964; R-HSA-9026007
RHEA: 10428