AmiGO 2: Term Details for "cytochrome-c oxidase activity" (GO:0004129)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0004129
Name: cytochrome-c oxidase activity
Ontology: molecular_function
Synonyms: cytochrome c oxidase activity, Warburg's respiratory enzyme activity, complex IV (mitochondrial electron transport) activity, cytochrome oxidase activity, aa3-type cytochrome c oxidase, ba3-type cytochrome c oxidase, caa3-type cytochrome c oxidase, cbb3-type cytochrome c oxidase, cytochrome a3 activity, cytochrome aa3 activity, indophenol oxidase, indophenolase
Alternate IDs: None
Definition: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. Source: RHEA:11436
Comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
History: See term history for GO:0004129 at QuickGO
Chem. react.: has participant water; has participant iron(3+); has participant dioxygen; has participant hydron; has participant iron(2+)
Subset: None
Related: Link to all genes and gene products annotated to cytochrome-c oxidase activity (excluding "regulates").; Link to all direct and indirect annotations to cytochrome-c oxidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cytochrome-c oxidase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0008150 biological_process
GO:0051179 localization
GO:0051234 establishment of localization
GO:0009987 cellular process
GO:0003674 molecular_function
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0006810 transport
GO:0098660 inorganic ion transmembrane transport
GO:0006812 monoatomic cation transport
GO:0034220 monoatomic ion transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0005215 transporter activity
GO:0022804 active transmembrane transporter activity
GO:0003824 catalytic activity
GO:0098662 inorganic cation transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0098655 monoatomic cation transmembrane transport
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0022890 inorganic cation transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0016491 oxidoreductase activity
GO:0015399 primary active transmembrane transporter activity
GO:1902600 proton transmembrane transport
GO:0022853 active monoatomic ion transmembrane transporter activity
GO:0009055 electron transfer activity
GO:0016675 oxidoreductase activity, acting on a heme group of donors
GO:0015453 oxidoreduction-driven active transmembrane transporter activity
GO:0015078 proton transmembrane transporter activity
GO:0004129 cytochrome-c oxidase activity
GO:1905376 negative regulation of cytochrome-c oxidase activity
GO:1904960 positive regulation of cytochrome-c oxidase activity
GO:1904959 regulation of cytochrome-c oxidase activity

Parents of cytochrome-c oxidase activity (GO:0004129)

subject	relation	object
cytochrome-c oxidase activity	is_a	oxidoreduction-driven active transmembrane transporter activity (GO:0015453)
cytochrome-c oxidase activity	is_a	proton transmembrane transporter activity (GO:0015078)
cytochrome-c oxidase activity	RO:0000057	water (CHEBI:15377)
cytochrome-c oxidase activity	RO:0000057	iron(3+) (CHEBI:29034)
cytochrome-c oxidase activity	is_a	active monoatomic ion transmembrane transporter activity (GO:0022853)
cytochrome-c oxidase activity	is_a	oxidoreductase activity, acting on a heme group of donors (GO:0016675)
cytochrome-c oxidase activity	RO:0000057	dioxygen (CHEBI:15379)
cytochrome-c oxidase activity	is_a	electron transfer activity (GO:0009055)
cytochrome-c oxidase activity	RO:0000057	hydron (CHEBI:15378)
cytochrome-c oxidase activity	RO:0000057	iron(2+) (CHEBI:29033)

Children of cytochrome-c oxidase activity (GO:0004129)

subject	relation	object
negative regulation of cytochrome-c oxidase activity (GO:1905376)	RO:0002212	cytochrome-c oxidase activity
regulation of cytochrome-c oxidase activity (GO:1904959)	RO:0002211	cytochrome-c oxidase activity
positive regulation of cytochrome-c oxidase activity (GO:1904960)	RO:0002213	cytochrome-c oxidase activity

EC: 7.1.1.9
MetaCyc: CYTOCHROME-C-OXIDASE-RXN
Reactome: R-HSA-163214
RHEA: 11436