AmiGO 2: Term Details for "dihydrofolate reductase activity" (GO:0004146)

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Term Information

Accession: GO:0004146
Name: dihydrofolate reductase activity
Ontology: molecular_function
Synonyms: dihydrofolate reduction, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity, 7,8-dihydrofolate reductase activity, DHFR, NADPH-dihydrofolate reductase activity, dihydrofolate reductase:thymidylate synthase activity, dihydrofolic acid reductase activity, dihydrofolic reductase activity, folic acid reductase activity, folic reductase activity, pteridine reductase:dihydrofolate reductase activity, tetrahydrofolate dehydrogenase activity, thymidylate synthetase-dihydrofolate reductase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. Source: EC:1.5.1.3
Comment: None
History: See term history for GO:0004146 at QuickGO
Chem. react.: has participant NADPH(4-); has participant hydron; has participant NADP(3-); has participant (6S)-5,6,7,8-tetrahydrofolate(2-); has participant dihydrofolate(2-)
Subset: None
Related: Link to all genes and gene products annotated to dihydrofolate reductase activity (excluding "regulates").; Link to all direct and indirect annotations to dihydrofolate reductase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for dihydrofolate reductase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0004146 dihydrofolate reductase activity

Parents of dihydrofolate reductase activity (GO:0004146)

subject	relation	object
dihydrofolate reductase activity	RO:0000057	NADPH(4-) (CHEBI:57783)
dihydrofolate reductase activity	is_a	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)
dihydrofolate reductase activity	RO:0000057	hydron (CHEBI:15378)
dihydrofolate reductase activity	RO:0000057	NADP(3-) (CHEBI:58349)
dihydrofolate reductase activity	RO:0000057	(6S)-5,6,7,8-tetrahydrofolate(2-) (CHEBI:57453)
dihydrofolate reductase activity	RO:0000057	dihydrofolate(2-) (CHEBI:57451)

This term has no children.

EC: 1.5.1.3
MetaCyc: DIHYDROFOLATEREDUCT-RXN
Reactome: R-HSA-1497794
RHEA: 15009