AmiGO 2: Term Details for "diphthine synthase activity" (GO:0004164)

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Term Information

Accession: GO:0004164
Name: diphthine synthase activity
Ontology: molecular_function
Synonyms: S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity, S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity, diphthine methyltransferase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine. Source: PMID:3042777, RHEA:36415, PMID:15485916, PMID:20873788
Comment: This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note tha this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which produces diphthine methyl ester.
History: See term history for GO:0004164 at QuickGO
Chem. react.: has participant S-adenosyl-L-methionine zwitterion; has participant S-adenosyl-L-homocysteine zwitterion; has participant hydron; has participant 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine zwitterion residue; has participant diphthine betaine residue
Subset: None
Related: Link to all genes and gene products annotated to diphthine synthase activity (excluding "regulates").; Link to all direct and indirect annotations to diphthine synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for diphthine synthase activity (excluding "regulates").

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016740 transferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0140096 catalytic activity, acting on a protein
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0004164 diphthine synthase activity

Parents of diphthine synthase activity (GO:0004164)

subject	relation	object
diphthine synthase activity	RO:0000057	S-adenosyl-L-methionine zwitterion (CHEBI:59789)
diphthine synthase activity	RO:0000057	S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
diphthine synthase activity	is_a	protein methyltransferase activity (GO:0008276)
diphthine synthase activity	RO:0000057	hydron (CHEBI:15378)
diphthine synthase activity	RO:0000057	2-[(3S)-3-amino-3-carboxypropyl]-L-histidine zwitterion residue (CHEBI:73995)
diphthine synthase activity	RO:0002160	Archaea (NCBITaxon:2157)
diphthine synthase activity	is_a	S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)
diphthine synthase activity	RO:0000057	diphthine betaine residue (CHEBI:82696)

This term has no children.

EC: 2.1.1.98
MetaCyc: RXN-14326
Reactome: R-HSA-5358484
RHEA: 36415