Term Information

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Accession
GO:0004222
Name
metalloendopeptidase activity
Ontology
molecular_function
Synonyms
metalloendoprotease activity, metalloendoproteinase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment
None
History
See term history for GO:0004222 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0004222 from QuickGO

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Parents of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metalloendopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
metalloendopeptidase activity [is_a relation] is_a  metallopeptidase activity (GO:0008237)
Children of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metalloendopeptidase inhibitor activity (GO:0008191) [RO:0002630 relation] RO:0002630  metalloendopeptidase activity
regulation of metalloendopeptidase activity (GO:1904683) [RO:0002211 relation] RO:0002211  metalloendopeptidase activity
negative regulation of metalloendopeptidase activity (GO:1904684) [RO:0002212 relation] RO:0002212  metalloendopeptidase activity
metalloendopeptidase activity involved in amyloid precursor protein catabolic process (GO:1902945) [is_a relation] is_a  metalloendopeptidase activity
positive regulation of metalloendopeptidase activity (GO:1904685) [RO:0002213 relation] RO:0002213  metalloendopeptidase activity
EC
3.4.24.69
3.4.24.61
3.4.24.64
3.4.24.55
3.4.24.57
3.4.24.56
3.4.24.59
3.4.24.35
3.4.24.34
3.4.24.37
3.4.24.22
3.4.24.21
3.4.24.24
3.4.24.23
3.4.24.11
3.4.24.7
3.4.24.14
3.4.24.17
3.4.24.-
3.4.24.3
3.4.24.19
3.4.24.18
3.4.24.71
3.4.24.70
3.4.24.72
MetaCyc
3.4.24.55-RXN
3.4.24.14-RXN
3.4.24.57-RXN
3.4.24.59-RXN
3.4.24.18-RXN
3.4.24.72-RXN
3.4.24.70-RXN
3.4.24.35-RXN
3.4.24.37-RXN
3.4.24.61-RXN
3.4.24.22-RXN
3.4.24.69-RXN
3.4.24.24-RXN
3.4.24.56-RXN
3.4.24.11-RXN
3.4.24.17-RXN
3.4.24.19-RXN
3.4.24.71-RXN
3.4.24.21-RXN
3.4.24.64-RXN
3.4.24.23-RXN
Reactome
R-HSA-5250606
R-HSA-2533944
R-HSA-8874201
R-HSA-8876868
R-HSA-2002428
R-HSA-5250962
R-HSA-1458433
R-HSA-1474196
R-HSA-2168046
R-HSA-2533950
R-HSA-194796
R-HSA-3791295
R-HSA-177946
R-HSA-2534248
R-HSA-1564184
R-HSA-2534240
R-HSA-194793
R-HSA-3791319
R-HSA-194818
R-HSA-1564179
R-HSA-2022141
R-HSA-2473594
R-HSA-2473596
R-HSA-2484882
R-HSA-5362793
R-HSA-3791149
R-HSA-194809
R-HSA-194808
R-HSA-1474210
R-HSA-2473584
R-HSA-8867344
R-HSA-1564169
R-HSA-3791155
R-HSA-1474213
R-HSA-1564164
R-HSA-6784620
R-HSA-2485148
R-HSA-5250892
R-HSA-8943959
R-HSA-1299476
R-HSA-381435
R-HSA-8949668
R-HSA-264758
R-HSA-1251992
R-HSA-420818
R-HSA-194800
R-HSA-1299478
R-HSA-8940959
R-HSA-8940554
R-HSA-1454822
R-HSA-1564143
R-HSA-8940561
R-HSA-5228578
R-HSA-2533874
R-HSA-5333671
R-HSA-8949659
R-HSA-181567
R-HSA-1564142
R-HSA-1655851
R-HSA-5694082
R-HSA-2514831
R-HSA-381537
R-HSA-8949649
R-HSA-1168777
R-HSA-2179402
R-HSA-1592310
R-HSA-2514790
R-HSA-3828025
R-HSA-3788075
R-HSA-3371385
R-HSA-381518
R-HSA-4086205
R-HSA-8874194
R-HSA-2533970
R-HSA-9624272
R-HSA-8874195
R-HSA-4224014
R-HSA-2168982
R-HSA-8877620
R-HSA-8874192
R-HSA-1564120
R-HSA-2537499
R-HSA-5250978
R-HSA-1454757
R-HSA-8940641
R-HSA-8942302
R-HSA-1564112
R-HSA-2002440
R-HSA-8874187
R-HSA-2485111
R-HSA-3827958
R-HSA-2533965
R-HSA-1564117