AmiGO 2: Term Details for "serine-type endopeptidase activity" (GO:0004252)

Term Information

Accession: GO:0004252
Name: serine-type endopeptidase activity
Ontology: molecular_function
Synonyms: blood coagulation factor activity, serine elastase activity
Alternate IDs: None
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment: None
History: See term history for GO:0004252 at QuickGO
Chem. react.: None
Subset: goslim_chembl
Related: Link to all genes and gene products annotated to serine-type endopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations to serine-type endopeptidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for serine-type endopeptidase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140096 catalytic activity, acting on a protein
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0017171 serine hydrolase activity
GO:0004175 endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:1900005 positive regulation of serine-type endopeptidase activity
GO:1900003 regulation of serine-type endopeptidase activity
GO:1905370 serine-type endopeptidase complex

Parents of serine-type endopeptidase activity (GO:0004252)

subject	relation	object
serine-type endopeptidase activity	is_a	endopeptidase activity (GO:0004175)
serine-type endopeptidase activity	is_a	serine-type peptidase activity (GO:0008236)

Children of serine-type endopeptidase activity (GO:0004252)

subject	relation	object
serine-type endopeptidase complex (GO:1905370)	RO:0002215	serine-type endopeptidase activity
positive regulation of serine-type endopeptidase activity (GO:1900005)	RO:0002213	serine-type endopeptidase activity
negative regulation of serine-type endopeptidase activity (GO:1900004)	RO:0002212	serine-type endopeptidase activity
regulation of serine-type endopeptidase activity (GO:1900003)	RO:0002211	serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity (GO:0004867)	RO:0002630	serine-type endopeptidase activity

EC: 3.4.21.-; 3.4.21.34; 3.4.21.36; 3.4.21.35; 3.4.21.38; 3.4.21.39; 3.4.21.21; 3.4.21.20; 3.4.21.22; 3.4.21.27; 3.4.21.26; 3.4.21.10; 3.4.21.9; 3.4.21.1; 3.4.21.5; 3.4.21.4; 3.4.21.7; 3.4.21.6; 3.4.21.73; 3.4.21.75; 3.4.21.78; 3.4.21.79; 3.4.21.71; 3.4.21.62; 3.4.21.69; 3.4.21.68; 3.4.21.61; 3.4.21.54; 3.4.21.53; 3.4.21.59; 3.4.21.41; 3.4.21.43; 3.4.21.42; 3.4.21.45; 3.4.21.47; 3.4.21.46; 3.4.21.48; 3.4.23.49; 3.4.21.102; 3.4.21.92; 3.4.21.94; 3.4.21.93; 3.4.21.89; 3.4.21.88; 3.4.21.83
MetaCyc: ACYLAMINOACYL-PEPTIDASE-RXN
Reactome: R-HSA-171288; R-HSA-159728; R-HSA-381466; R-HSA-2168960; R-HSA-166817; R-HSA-158750; R-HSA-1602473; R-HSA-381461; R-HSA-174551; R-HSA-2172405; R-HSA-2022411; R-HSA-140664; R-HSA-158747; R-HSA-3785684; R-HSA-158982; R-HSA-158744; R-HSA-1604763; R-HSA-183130; R-HSA-1602466; R-HSA-9708859; R-HSA-170844; R-HSA-9694661; R-HSA-2129357; R-HSA-6800198; R-HSA-1602458; R-HSA-381446; R-HSA-9710263; R-HSA-140777; R-HSA-173680; R-HSA-1604752; R-HSA-183122; R-HSA-5210935; R-HSA-139893; R-HSA-158164; R-HSA-1912372; R-HSA-2168923; R-HSA-1592297; R-HSA-381798; R-HSA-1454843; R-HSA-140769; R-HSA-8874145; R-HSA-1604741; R-HSA-422021; R-HSA-1604690; R-HSA-1592314; R-HSA-1592316; R-HSA-9033530; R-HSA-9023178; R-HSA-1592436; R-HSA-9662786; R-HSA-1566962; R-HSA-5578783; R-HSA-140599; R-HSA-2534160; R-HSA-158311; R-HSA-158313; R-HSA-9829200; R-HSA-9033524; R-HSA-9033529; R-HSA-9699007; R-HSA-9686731; R-HSA-9033520; R-HSA-381135; R-HSA-3814820; R-HSA-6800200; R-HSA-1799329; R-HSA-158300; R-HSA-9033515; R-HSA-9830882; R-HSA-140696; R-HSA-158419; R-HSA-3788061; R-HSA-2534260; R-HSA-159868; R-HSA-8852716; R-HSA-9033506; R-HSA-3266557; R-HSA-9686710; R-HSA-9653249; R-HSA-163798; R-HSA-8874186; R-HSA-5591040; R-HSA-1602484; R-HSA-158766; R-HSA-159733; R-HSA-1602488; R-HSA-186785; R-HSA-2514772; R-HSA-400459; R-HSA-9694287; R-HSA-8874204; R-HSA-8874206; R-HSA-8874205; R-HSA-1474197; R-HSA-381500; R-HSA-173745; R-HSA-1592362; R-HSA-173626; R-HSA-1181152; R-HSA-5607002; R-HSA-9670874; R-HSA-422051; R-HSA-1604360; R-HSA-2471842; R-HSA-9673223; R-HSA-977371; R-HSA-9666383; R-HSA-140700; R-HSA-140823; R-HSA-159796; R-HSA-2482180; R-HSA-1604368; R-HSA-3928657; R-HSA-9023633; R-HSA-1566979; R-HSA-9023196; R-HSA-9023632; R-HSA-9769949; R-HSA-9698988; R-HSA-1566981; R-HSA-1604359; R-HSA-6801687; R-HSA-158333; R-HSA-2214330; R-HSA-166753; R-HSA-400492; R-HSA-9023627; R-HSA-9023626; R-HSA-400496; R-HSA-159771; R-HSA-8865275; R-HSA-8865276; R-HSA-159773; R-HSA-1592278; R-HSA-9668253; R-HSA-6800299; R-HSA-2534206; R-HSA-141040; R-HSA-187020; R-HSA-1912369; R-HSA-1604732; R-HSA-140870; R-HSA-1604731; R-HSA-5210912; R-HSA-9770187; R-HSA-8850831; R-HSA-9710106; R-HSA-1604722; R-HSA-1592270; R-HSA-9668365; R-HSA-1592398; R-HSA-8849857; R-HSA-9033490; R-HSA-9829030; R-HSA-382061; R-HSA-977615; R-HSA-265301; R-HSA-158942; R-HSA-9830805; R-HSA-5691512; R-HSA-1604712; R-HSA-141026; R-HSA-163843; R-HSA-1655842; R-HSA-2514823; R-HSA-140736; R-HSA-9655046; R-HSA-166792; R-HSA-158137; R-HSA-114697; R-HSA-6807224; R-HSA-8849826; R-HSA-8874212; R-HSA-2471621; R-HSA-8855825; R-HSA-140840; R-HSA-173631; R-HSA-1592371; R-HSA-158925; R-HSA-976743