AmiGO 2: Term Details for "tetrahydrofolylpolyglutamate synthase activity" (GO:0004326)

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Term Information

Accession: GO:0004326
Name: tetrahydrofolylpolyglutamate synthase activity
Ontology: molecular_function
Synonyms: folylpolyglutamate synthase activity, FPGS activity, N(10)-formyltetrahydropteroyldiglutamate synthetase activity, N10-formyltetrahydropteroyldiglutamate synthetase activity, folate polyglutamate synthetase activity, folylpoly(gamma-glutamate) synthase activity, folylpoly-gamma-glutamate synthase activity, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity, folylpolyglutamate synthetase activity, folylpolyglutamyl synthetase activity, formyltetrahydropteroyldiglutamate synthetase activity, tetrahydrofolate synthase activity, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity, tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)
Alternate IDs: None
Definition: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). Source: EC:6.3.2.17
Comment: None
History: See term history for GO:0004326 at QuickGO
Chem. react.: has participant L-glutamate(1-); has participant hydron; has participant ATP(4-); has participant ADP(3-); has participant (6S)-5,6,7,8-tetrahydrofolyl-poly(gamma-glutamate) macromolecule; has participant hydrogenphosphate
Subset: None
Related: Link to all genes and gene products annotated to tetrahydrofolylpolyglutamate synthase activity (excluding "regulates").; Link to all direct and indirect annotations to tetrahydrofolylpolyglutamate synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for tetrahydrofolylpolyglutamate synthase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0009987 cellular process
GO:0071704 organic substance metabolic process
GO:0044237 cellular metabolic process
GO:0003674 molecular_function
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:1901564 organonitrogen compound metabolic process
GO:0003824 catalytic activity
GO:0006575 cellular modified amino acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0042398 cellular modified amino acid biosynthetic process
GO:0006760 folic acid-containing compound metabolic process
GO:0016874 ligase activity
GO:0042559 pteridine-containing compound biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0046900 tetrahydrofolylpolyglutamate metabolic process
GO:0016881 acid-amino acid ligase activity
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
GO:0004326 tetrahydrofolylpolyglutamate synthase activity

Parents of tetrahydrofolylpolyglutamate synthase activity (GO:0004326)

subject	relation	object
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	L-glutamate(1-) (CHEBI:29985)
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	hydron (CHEBI:15378)
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	ATP(4-) (CHEBI:30616)
tetrahydrofolylpolyglutamate synthase activity	BFO:0000050	tetrahydrofolylpolyglutamate biosynthetic process (GO:0046901)
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	ADP(3-) (CHEBI:456216)
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	(6S)-5,6,7,8-tetrahydrofolyl-poly(gamma-glutamate) macromolecule (CHEBI:141005)
tetrahydrofolylpolyglutamate synthase activity	is_a	acid-amino acid ligase activity (GO:0016881)
tetrahydrofolylpolyglutamate synthase activity	RO:0000057	hydrogenphosphate (CHEBI:43474)

This term has no children.

EC: 6.3.2.17
MetaCyc: FOLYLPOLYGLUTAMATESYNTH-RXN
Reactome: R-HSA-197958; R-HSA-200681; R-HSA-200682
RHEA: 10580