AmiGO 2: Term Details for "glucosylceramidase activity" (GO:0004348)

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Term Information

Accession: GO:0004348
Name: glucosylceramidase activity
Ontology: molecular_function
Synonyms: D-glucosyl-N-acylsphingosine glucohydrolase activity, GlcCer-beta-glucosidase activity, acid beta-glucosidase activity, beta-D-glucocerebrosidase activity, beta-glucocerebrosidase activity, beta-glucosylceramidase activity, ceramide glucosidase activity, glucocerebrosidase activity, glucosphingosine glucosylhydrolase activity, glucosylcerebrosidase activity, glucosylsphingosine beta-D-glucosidase activity, glucosylsphingosine beta-glucosidase activity, psychosine hydrolase activity
Alternate IDs: None
Definition: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. Source: EC:3.2.1.45
Comment: None
History: See term history for GO:0004348 at QuickGO
Chem. react.: has participant water; has participant N-acylsphingosine; has participant D-glucopyranose; has participant beta-D-glucosyl-N-acylsphingosine
Subset: None
Related: Link to all genes and gene products annotated to glucosylceramidase activity (excluding "regulates").; Link to all direct and indirect annotations to glucosylceramidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for glucosylceramidase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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OLSVis (interactive)

Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004348 glucosylceramidase activity
GO:1905124 negative regulation of glucosylceramidase activity
GO:1905125 positive regulation of glucosylceramidase activity
GO:1905123 regulation of glucosylceramidase activity

Parents of glucosylceramidase activity (GO:0004348)

subject	relation	object
glucosylceramidase activity	RO:0000057	water (CHEBI:15377)
glucosylceramidase activity	is_a	hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
glucosylceramidase activity	RO:0000057	N-acylsphingosine (CHEBI:52639)
glucosylceramidase activity	RO:0000057	D-glucopyranose (CHEBI:4167)
glucosylceramidase activity	RO:0000057	beta-D-glucosyl-N-acylsphingosine (CHEBI:22801)

Children of glucosylceramidase activity (GO:0004348)

subject	relation	object
regulation of glucosylceramidase activity (GO:1905123)	RO:0002211	glucosylceramidase activity
negative regulation of glucosylceramidase activity (GO:1905124)	RO:0002212	glucosylceramidase activity
positive regulation of glucosylceramidase activity (GO:1905125)	RO:0002213	glucosylceramidase activity

EC: 3.2.1.45
MetaCyc: GLUCOSYLCERAMIDASE-RXN
Reactome: R-HSA-1605591; R-HSA-1861788; R-HSA-1861789
RHEA: 13269