Term Information

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Accession
GO:0004357
Name
glutamate-cysteine ligase activity
Ontology
molecular_function
Synonyms
L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity, gamma-glutamyl-L-cysteine synthetase activity, gamma-glutamylcysteine synthetase activity, gamma-glutamylcysteinyl synthetase activity
Alternate IDs
None
Definition
Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. Source: RHEA:13285, EC:6.3.2.2
Comment
None
History
See term history for GO:0004357 at QuickGO
Chem. react.
has participant L-cysteine zwitterion
has participant L-gamma-glutamyl-L-cysteinate(1-)
has participant hydrogenphosphate
has participant L-glutamate(1-)
has participant ADP(3-)
has participant hydron
has participant ATP(4-)
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of glutamate-cysteine ligase activity (GO:0004357)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  L-cysteine zwitterion (CHEBI:35235)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  L-gamma-glutamyl-L-cysteinate(1-) (CHEBI:58173)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  hydrogenphosphate (CHEBI:43474)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  L-glutamate(1-) (CHEBI:29985)
glutamate-cysteine ligase activity [is_a relation] is_a  acid-amino acid ligase activity (GO:0016881)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  ADP(3-) (CHEBI:456216)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
glutamate-cysteine ligase activity [RO:0000057 relation] RO:0000057  ATP(4-) (CHEBI:30616)
Children of glutamate-cysteine ligase activity (GO:0004357)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of glutamate-cysteine ligase activity (GO:0035228) [RO:0002212 relation] RO:0002212  glutamate-cysteine ligase activity
glutamate-cysteine ligase regulator activity (GO:1990609) [RO:0002578 relation] RO:0002578  glutamate-cysteine ligase activity
glutamate-cysteine ligase complex (GO:0017109) [RO:0002215 relation] RO:0002215  glutamate-cysteine ligase activity
regulation of glutamate-cysteine ligase activity (GO:0035227) [RO:0002211 relation] RO:0002211  glutamate-cysteine ligase activity
positive regulation of glutamate-cysteine ligase activity (GO:0035229) [RO:0002213 relation] RO:0002213  glutamate-cysteine ligase activity
EC
6.3.2.2
KEGG_REACTION
R00894
MetaCyc
GLUTCYSLIG-RXN
Reactome
R-HSA-5602892
R-HSA-174367
RHEA
13285