AmiGO 2: Term Details for "glutathione-disulfide reductase (NADPH) activity" (GO:0004362)

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Term Information

Accession: GO:0004362
Name: glutathione-disulfide reductase (NADPH) activity
Ontology: molecular_function
Synonyms: glutathione reductase activity, glutathione-disulfide reductase (NADP) activity, glutathione-disulfide reductase activity, glutathione-disulphide reductase activity, GSH reductase activity, GSSG reductase activity, NADPH-GSSG reductase activity, NADPH-glutathione reductase activity, NADPH:oxidized-glutathione oxidoreductase activity, glutathione S-reductase activity, glutathione:NADP+ oxidoreductase activity, oxidized glutathione reduction
Alternate IDs: None
Definition: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. Source: RHEA:11740, PMID:36771108
Comment: Note that this function was formerly EC:1.6.4.2.
History: See term history for GO:0004362 at QuickGO
Chem. react.: has participant glutathione disulfide(2-); has participant NADPH(4-); has participant glutathionate(1-); has participant hydron; has participant NADP(3-)
Subset: None
Related: Link to all genes and gene products annotated to glutathione-disulfide reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations to glutathione-disulfide reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for glutathione-disulfide reductase (NADPH) activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
GO:0008150 biological_process
UBERON:0001062 anatomical entity
GO:0009987 cellular process
CARO:0000006 material anatomical entity
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0042221 response to chemical
UBERON:0000061 anatomical structure
GO:0070887 cellular response to chemical stimulus
GO:0003674 molecular_function
GO:0009636 response to toxic substance
GO:0003824 catalytic activity
CL:0000000 cell
GO:0097237 cellular response to toxic substance
GO:0098754 detoxification
GO:1990748 cellular detoxification
GO:0016491 oxidoreductase activity
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0098869 cellular oxidant detoxification
GO:0015036 disulfide oxidoreductase activity
GO:0016209 antioxidant activity
GO:0015038 glutathione disulfide oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0004362 glutathione-disulfide reductase (NADPH) activity

Parents of glutathione-disulfide reductase (NADPH) activity (GO:0004362)

subject	relation	object
glutathione-disulfide reductase (NADPH) activity	RO:0000057	glutathione disulfide(2-) (CHEBI:58297)
glutathione-disulfide reductase (NADPH) activity	RO:0000057	NADPH(4-) (CHEBI:57783)
glutathione-disulfide reductase (NADPH) activity	RO:0000057	glutathionate(1-) (CHEBI:57925)
glutathione-disulfide reductase (NADPH) activity	is_a	glutathione disulfide oxidoreductase activity (GO:0015038)
glutathione-disulfide reductase (NADPH) activity	is_a	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor (GO:0016668)
glutathione-disulfide reductase (NADPH) activity	is_a	antioxidant activity (GO:0016209)
glutathione-disulfide reductase (NADPH) activity	RO:0000057	hydron (CHEBI:15378)
glutathione-disulfide reductase (NADPH) activity	RO:0000057	NADP(3-) (CHEBI:58349)

This term has no children.

EC: 1.8.1.7
MetaCyc: GLUTATHIONE-REDUCT-NADPH-RXN
Reactome: R-HSA-3323079; R-HSA-71682
RHEA: 11740